Lions vs. 49ers Prediction: Detroit Predicted to Win MNF Week 17 [2024]

The San Francisco 49ers and Detroit Lions are scheduled to meet in Week 17 of the NFL season at Levi's Stadium on Monday, with kickoff at 8:15PM ET.

Based on updated simulation results, Dimers' proven NFL model (see Dimers Pro for full access) projects the Lions as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's Detroit-San Francisco game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Lions are likely to win, with a probability of 63%, compared to the 49ers' 37%."

This updated Lions vs. 49ers betting preview builds on my early Lions vs. 49ers prediction that I released at the start of the week.

For a closer look at today’s game, including the predicted score, best bets and player prop picks, visit our interactive Lions vs. 49ers predictions page.

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Lions vs. 49ers Game-Day Updates and Essential Details

The NFL Week 17 game between the 49ers and Lions at Levi's Stadium is scheduled to begin at 8:15PM ET.

• Who: Detroit Lions vs. San Francisco 49ers
• Date: Monday, December 30, 2024
• Time: 8:15PM ET/5:15PM PT
• Venue: Levi's Stadium
• Tickets: Get tickets for the game on Ticketmaster
• Merchandise: Buy 49ers and Lions gear at Fanatics

Dimers.com's in-depth preview of Monday's Lions vs. 49ers matchup includes our prediction, picks and the latest betting odds.

Before making any Detroit vs. San Francisco picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

Lions vs. 49ers Predictions

Using innovative machine learning and data, we have simulated the result of Monday's NFL matchup between the Lions and 49ers 10,000 times as part of our NFL predictions coverage.

Our leading predictive model currently gives the Lions a 63% chance of beating the 49ers in Week 17 of the NFL season. Our predicted final score has the Lions winning 26-22.

According to our model, the Lions (-3.5) have a 52% chance of covering the spread, while the 50.5-point over/under has a 53% chance of staying under.

Lions vs. 49ers Odds

We have researched the best betting odds in America for this game, which are listed here:

Bet Type	Lions	49ers
Spread	-3.5 (-110)	+3.5 (-110)
Moneyline	-205	+200
Total	o50.5 (-108)	u50.5 (-110)

All odds are correct at the time of publication and are subject to change.

Lions vs. 49ers Picks

Our model's strongest edge in today's Lions vs. 49ers matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best NFL picks for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Lions vs. 49ers TD Scorers

Who will score an anytime touchdown in Lions vs. 49ers?

According to our model, Detroit's Jahmyr Gibbs is most likely to score the first TD in Lions vs. 49ers.

Our projections give Gibbs a 17.3% chance of scoring the first TD at Levi's Stadium, while the Lions RB is a 66.8% chance of scoring an anytime touchdown.

First Touchdown Scorer Predictions

Detroit Lions

Player	First TD Probability
Jahmyr Gibbs	17.3%
Amon-Ra St. Brown	10.4%
Jameson Williams	8.1%

San Francisco 49ers

Player	First TD Probability
Deebo Samuel	9.6%
George Kittle	8.9%
Isaac Guerendo	8.4%

Anytime Touchdown Scorer Predictions

Detroit Lions

Player	Anytime TD Probability
Jahmyr Gibbs	66.8%
Amon-Ra St. Brown	47.0%
Jameson Williams	38.6%

San Francisco 49ers

Player	Anytime TD Probability
Deebo Samuel	45.0%
Isaac Guerendo	42.1%
George Kittle	41.0%

Lions vs 49ers Player Props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Lions and 49ers. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Lions-49ers page now to access every player prop projection.

Lions vs. 49ers Quarterbacks

Of the starting quarterbacks, the Lions' Jared Goff is projected to throw for fewer yards than the 49ers' Brock Purdy.

Lions Rushing

Jahmyr Gibbs, Craig Reynolds and Jermar Jefferson are projected to be the leading rushers for the Lions.

Player	Position
Jahmyr Gibbs	RB
Craig Reynolds	RB
Jermar Jefferson	RB

49ers Rushing

Isaac Guerendo, Deebo Samuel and Brock Purdy are expected to lead the 49ers in rushing yards.

Player	Position
Isaac Guerendo	RB
Deebo Samuel	WR
Brock Purdy	QB

Lions Receiving

Amon-Ra St. Brown, Jameson Williams, Sam LaPorta, Tim Patrick and Jahmyr Gibbs are projected to top the receiving yards for the Lions.

Player	Position
Amon-Ra St. Brown	WR
Jameson Williams	WR
Sam LaPorta	TE
Tim Patrick	WR
Jahmyr Gibbs	RB

49ers Receiving

George Kittle, Jauan Jennings, Deebo Samuel, Ricky Pearsall and Isaac Guerendo are projected to lead the 49ers in receiving yards.

Player	Position
George Kittle	TE
Jauan Jennings	WR
Deebo Samuel	WR
Ricky Pearsall	WR
Isaac Guerendo	RB

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Conclusion

We predict the Lions, with a 63% win probability, will likely beat the 49ers in Week 17 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Lions vs. 49ers insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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