Detroit Lions vs. San Francisco 49ers Early Predictions for NFL Week 17: Odds, Picks and Preview [2024]

The San Francisco 49ers and Detroit Lions will lock horns in Week 17 of the NFL season at Levi's Stadium on Monday, December 30, 2024, with kickoff set for 8:15PM ET.

Early simulations from Dimers' advanced NFL model favor the Lions as the most likely winner of this game.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Lions vs. 49ers predictions page.

Lions vs. 49ers Week 17 Details

The NFL Week 17 action between the 49ers and Lions at Levi's Stadium is scheduled for December 30, 2024.

• Who: Detroit Lions vs. San Francisco 49ers
• Date: Monday, December 30, 2024
• Time: 8:15PM ET/5:15PM PT
• Venue: Levi's Stadium

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Lions vs. 49ers Latest Odds

We've researched the best betting odds in America for this Week 17 game, which are listed here:

• Spread: Lions -3.5 (-110), 49ers +3.5 (-108)
• Moneyline: Lions -190, 49ers +166
• Total: Over/Under 51 (-112/-108)

Detroit vs. San Francisco Early Predictions

Leveraging trusted machine learning and analysis, we have simulated the Lions vs. 49ers game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight Up Win Probabilities: Lions 62%, 49ers 38%
• Predicted Final Score: Lions 26-23 49ers
• Spread: Lions (-3.5) 50%, 49ers (+3.5) 50%
• Total Points (51): Over 46%, Under 54%

As of December 24, 2024, these Lions-49ers predictions reflect the latest data and insights available.

Anytime Touchdown Scorer Predictions

Here are our preliminary touchdown probabilities for the Lions-49ers game:

Detroit Lions

• Jahmyr Gibbs: 65.1% probability
• Amon-Ra St. Brown: 48.5% probability
• Jameson Williams: 39.3% probability

San Francisco 49ers

• Deebo Samuel: 45.4% probability
• Isaac Guerendo: 42.8% probability
• George Kittle: 41.6% probability

Lions vs 49ers Player Props

Jahmyr Gibbs is projected to lead rushing for the Lions, while Isaac Guerendo is expected to pace the 49ers on the ground.

In the receiving game, our projections favor Detroit's Amon-Ra St. Brown and San Francisco's George Kittle as the likely leaders for each team.

Conclusion

We predict the Lions, with a 62% win probability, will likely beat the 49ers in Week 17 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Lions vs. 49ers matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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