Detroit Lions vs. San Francisco 49ers Early Prediction for NFL Week 17 [2024]

The San Francisco 49ers and Detroit Lions will meet in Week 17 of the NFL season at Levi's Stadium on Monday, December 30, 2024, starting at 8:15PM ET.

Based on early simulations, Dimers' proven NFL model (see Dimers Pro for full access) predicts the 49ers as the most likely winner of this Week 17 game.

Lions vs. 49ers Essential Details

The NFL Week 17 game between the 49ers and Lions at Levi's Stadium is scheduled for December.

• Who: Detroit Lions vs. San Francisco 49ers
• Date: Monday, December 30, 2024
• Time: 8:15PM ET/5:15PM PT
• Venue: Levi's Stadium
• Tickets: Get tickets for the game on Ticketmaster

Before making any Lions vs. 49ers picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

Detroit vs. San Francisco Early Prediction: 49ers Favored to Win by Model

Using powerful machine learning and analysis, we have simulated the result of the NFL Week 17 matchup between the Lions and 49ers 10,000 times as part of our NFL predictions coverage.

Our leading predictive model gives the 49ers a 62% chance of defeating the Lions in Week 17 of the NFL season. Our predicted final score has the 49ers winning 25-22.

According to our early outlook, the Lions (+4.5) have a 54% chance of covering the spread, while the over/under total of 49.5 points has a 56% chance of staying under.

As of July 2024, these Lions-49ers predictions reflect the most up-to-date data and insights available.

Conclusion

We predict the 49ers, with a 62% win probability, will likely beat the Lions in Week 17 of the NFL season.

Dimers.com will have full coverage of the game closer to kickoff, so stay tuned for more updates.

AI and automation have enhanced this article to quickly deliver accurate Lions vs. 49ers insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee.

More on NFL

Stay well-informed with the latest NFL news and our data-led parlay picks all season long. Plus, our Super Bowl odds give you the latest probabilities and the best available odds on the Super Bowl, AFC, NFC, and each division.