Cubs vs. Reds Prediction and Odds - Oct 5, 2022

The Cincinnati Reds and Chicago Cubs clash in MLB at Great American Ball Park on Wednesday, starting at 4:10PM ET.

Graham Ashcraft (5-5, 4.52 ERA) will start on the mound for the Reds, while the Cubs will counter with Adrian Sampson (4-5, 3.10 ERA).

Dimers' free betting picks for Cubs vs. Reds, plus game predictions and best odds, are featured below.

Who will win Cubs vs. Reds?

Using advanced computer power and data, Dimers.com has simulated Wednesday's Cubs-Reds MLB game 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, gives the Reds a 52% chance of defeating the Cubs.

More: Cubs vs. Reds Simulated 10,000 Times

Cubs vs. Reds Odds

• Run Line: Reds +1.5 (-150), Cubs -1.5 (+135)
• Moneyline: Reds +112, Cubs -120
• Total: Over/Under 8.5 (-120/+102)

Run Line, Moneyline and Over/Under

The Reds are +1.5 underdogs versus the Cubs, with -150 at DraftKings Sportsbook the best odds currently available.

For the favored Cubs (-1.5) to cover the run line, BetMGM has the best odds currently on offer at +135.

FanDuel Sportsbook currently has the best moneyline odds for the Reds at +112, which means you can bet $100 to profit $112, earning a total payout of $212, if they win.

On the other hand, BetMGM currently has the best moneyline odds for the Cubs at -120, where you can risk $120 to win $100, for a total payout of $220, if they come out on top.

The Over/Under for total runs scored is set at 8.5 with BetMGM, which currently has the best odds for the Over at -120, while FanDuel Sportsbook currently has the best odds for the Under at +102.

As always, check out all the sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Reds (+1.5) are a 63% chance of covering the run line, while the Over/Under total of 8.5 runs is a 58% chance of going Over.

More: Free Online Bet Tracker

Best Bets for Cubs vs. Reds

• Run Line: Reds +1.5 @ -150 via DraftKings Sportsbook (63% probability)
• Moneyline: Reds @ +112 via FanDuel Sportsbook (52% probability) 🔥
• Total: Over 8.5 @ -120 via BetMGM (58% probability)

If you see a 🔥, that means you've found one of our best bets of the day across any sport.

Dimers' best bets are based on world-class simulations and wagering intelligence to help you make more informed investments with the legal sportsbooks in your state.

Cubs vs. Reds Prediction

Click or tap on See Matchup to reveal more.

Dimers has full betting coverage of Wednesday's Cubs-Reds matchup, including pregame predictions, best betting picks, and live win probabilities.

Remember, DimersBOT updates frequently, so refresh this article for any changes to our betting analysis before Cubs vs. Reds on Wednesday October 5, 2022.

Cubs vs. Reds 2022 Game Info

Wednesday's game between the Reds and Cubs at Great American Ball Park is scheduled to begin at 4:10PM ET.

• Who: Chicago Cubs vs. Cincinnati Reds
• Date: Wednesday October 5, 2022
• Time: 4:10PM ET / 1:10PM PT
• Venue: Great American Ball Park

Looking to join an online sportsbook and start betting on MLB? We've listed the best available sign-up offers in every legal betting state.

Want more MLB previews like this?

So, you liked our Cubs vs. Reds betting predictions? Awesome. Did you know our MLB Betting News section has a detailed betting preview for every MLB matchup as soon as the sportsbooks put out their odds?

That's right, our predictive analytics model then compares those odds against its own probabilities to find value in the markets, which allows us to produce the most authoritative MLB betting previews and beat the public and the sportsbooks to the punch.

It's only a click away, so why not see for yourself?

Lastly, Dimers' Baseball Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities matched against the best odds available.