Cubs vs. Pirates Prediction and Odds - Sep 25, 2022

The Pittsburgh Pirates face the Chicago Cubs in MLB action at PNC Park on Sunday, beginning at 1:35PM ET.

Luis Ortiz (0-0, 0.84 ERA) will be on the bump for the Pirates, while the Cubs will counter with Adrian Sampson (2-5, 3.35 ERA).

Dimers' free betting picks for Cubs vs. Pirates, as well as game predictions and betting odds, are detailed below.

Who will win Cubs vs. Pirates?

Using state-of-the-art computer power and data, Dimers.com has simulated Sunday's Cubs-Pirates MLB matchup 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, currently gives the Pirates a 57% chance of beating the Cubs.

More: Cubs vs. Pirates Simulated 10K Times

Cubs vs. Pirates Current Odds

• Run Line: Pirates -1.5 (+162), Cubs +1.5 (-189)
• Moneyline: Pirates -130, Cubs +115
• Total: Over/Under 8 (-115/+100)

Run Line, Moneyline and Over/Under

The Pirates are -1.5 favorites versus the Cubs, with +162 at FanDuel Sportsbook the best odds currently available.

For the underdog Cubs (+1.5) to cover the run line, Caesars Sportsbook has the best odds currently on offer at -189.

BetMGM currently has the best moneyline odds for the Pirates at -130. That means you can risk $130 to win $100, for a total payout of $230, if they get the W.

On the other hand, DraftKings Sportsbook currently has the best moneyline odds for the Cubs at +115, where you can put down $100 to profit $115, earning a total payout of $215, if they win.

The Over/Under for total runs scored sits at 8 with BetMGM, which currently has the best odds for the Over at -115, while DraftKings Sportsbook currently has the best odds for the Under at +100.

As always, make sure you check the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Cubs (+1.5) are a 61% chance of covering the run line, while the 8-run Over/Under is a 53% chance of going Over.

More: Track Your Bets via Bet Center

Best Bets for Cubs vs. Pirates

• Run Line: Pirates -1.5 @ +162 via FanDuel Sportsbook (1.1% edge)
• Moneyline: Pirates @ -130 via BetMGM (57% probability)
• Total: Over 8 @ -115 via BetMGM (53% probability)

Our best bets are based on world-class modeling and betting expertise to bring you the best possible plays every day of the year.

Although the Cubs are more likely to cover the run line, our best bet of Pirates -1.5 is based on the expectation of that happening, according to DimersBOT, and the top odds available.

Cubs vs. Pirates Prediction

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Dimers has full betting coverage of Sunday's Cubs-Pirates matchup, including pregame predictions, best betting picks, and live win probabilities.

Remember, DimersBOT updates regularly, so keep an eye on this article for the latest betting insights ahead of Cubs vs. Pirates on Sunday September 25, 2022.

Cubs vs. Pirates 2022 Game Info

Sunday's game between the Pirates and Cubs at PNC Park is scheduled to commence at 1:35PM ET.

• Who: Chicago Cubs vs. Pittsburgh Pirates
• Date: Sunday September 25, 2022
• Time: 1:35PM ET / 10:35AM PT
• Venue: PNC Park

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Finally, Dimers' Baseball Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities paired with the best odds to win the World Series.