Cubs vs. Marlins Prediction and Odds - Sep 21, 2022

MLB action continues on Wednesday at 6:40PM ET as the Chicago Cubs square off with the Miami Marlins at loanDepot park.

Jesús Luzardo (3-7, 3.75 ERA) will get the ball for the Marlins, while the Cubs are going with Marcus Stroman (4-7, 3.76 ERA).

Dimers' free betting picks for Cubs vs. Marlins, as well as game predictions and betting odds, are featured below.

Who will win Cubs vs. Marlins?

Using cutting-edge machine learning and data, Dimers.com has simulated Wednesday's Cubs-Marlins MLB game 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, currently gives the Marlins a 55% chance of defeating the Cubs.

More: Full Betting Guide for Cubs vs. Marlins

Cubs vs. Marlins Game Odds

• Run Line: Marlins +1.5 (-200), Cubs -1.5 (+175)
• Moneyline: Marlins -110, Cubs -104
• Total: Over/Under 6.5 (-120/+105)

Run Line, Moneyline and Over/Under

The Marlins are currently +1.5 underdogs against the Cubs, with -200 at BetMGM the best odds currently available.

For the favored Cubs (-1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on offer at +175.

In a sign of how close this game is expected to be, both the Marlins and Cubs are currently at minus-money betting odds to win on Wednesday.

BetMGM currently has the best moneyline odds for the Marlins at -110. That means you can risk $110 to win $100, for a total payout of $210, if they get the W.

On the other hand, FanDuel Sportsbook currently has the best moneyline odds for the Cubs at -104, where you can risk $104 to win $100, for a total payout of $204, if they come out on top.

The Over/Under for total runs scored is set at 6.5 with BetMGM, which currently has the best odds for the Over at -120, while DraftKings Sportsbook currently has the best odds for the Under at +105.

As always, check out the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Marlins (+1.5) are a 69% chance of covering the run line, while the 6.5-run Over/Under is a 53% chance of going Over.

More: Free Prop Picks

Best Bets for Cubs vs. Marlins

• Run Line: Marlins +1.5 @ -200 via BetMGM (69% probability)
• Moneyline: Marlins @ -110 via BetMGM (55% probability)
• Total: Over 6.5 @ -120 via BetMGM (53% probability)

Our best bets are based on world-class simulations and betting intelligence to serve you the best possible plays 24/7/365.

Cubs vs. Marlins Prediction

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Dimers has full betting coverage of Wednesday's Cubs-Marlins matchup, including pregame predictions, computer picks, and live scores.

Remember, DimersBOT updates often, so keep an eye on this article for any changes to our betting analysis ahead of Cubs vs. Marlins on Wednesday September 21, 2022.

Cubs vs. Marlins 2022 Game Info

Wednesday's matchup between the Marlins and Cubs at loanDepot park is scheduled to start at 6:40PM ET.

• Who: Chicago Cubs vs. Miami Marlins
• Date: Wednesday September 21, 2022
• Time: 6:40PM ET / 3:40PM PT
• Venue: loanDepot park

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What other MLB games are on today?

The Cubs and Marlins aren't the only two MLB teams you can bet on today. DimersBOT never stops and we've got picks and top bets for every single MLB matchup via our MLB Predictions section.

Not only do we provide with you great predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Check it out today!

While you're here, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds on the market.