Colts vs. Jaguars Week 2 Prediction and Odds - Sep 18, 2022

The Jacksonville Jaguars take on the Indianapolis Colts in NFL Week 2 action at TIAA Bank Field on Sunday, beginning at 1:00PM ET.

Dimers' free betting picks for Colts vs. Jaguars, plus game predictions, betting odds and touchdown scorer probabilities, are detailed in this article.

This Indianapolis vs. Jacksonville betting analysis is sponsored by FanDuel Sportsbook, which has a No Sweat First Bet bonus up to $1,000 for new customers.

Who will win Colts vs. Jaguars?

Using cutting-edge machine learning and data, Dimers.com has simulated Sunday's Colts-Jaguars NFL game 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, gives the Colts a 60% chance of beating the Jaguars in Week 2 of the NFL season.

More: Colts vs. Jaguars Simulated 10,000 Times

Colts vs. Jaguars Current Odds

• Spread: Jaguars +3 (-104), Colts -3 (-110)
• Moneyline: Jaguars +142, Colts -155
• Total: Over/Under 43.5 (-107/-107)

Point Spread, Moneyline and Over/Under

The Jaguars are currently +3 underdogs against the Colts, with -104 at FanDuel Sportsbook the best odds currently available.

For the favored Colts (-3) to cover the spread, Caesars Sportsbook has the best odds currently on offer at -110.

FanDuel Sportsbook currently has the best moneyline odds for the Jaguars at +142. That means you can bet $100 to profit $142, earning a total payout of $242, if they win.

On the other hand, DraftKings Sportsbook currently has the best moneyline odds for the Colts at -155, where you can risk $155 to win $100, for a total payout of $255, if they come out on top.

The Over/Under sits at 43.5 with PointsBet, which currently has the best odds for the Over at -107, as well as the best odds for the Under at -107.

As always, make sure you check all of the online sportsbooks that are available in your state for the best NFL odds and lines.

According to DimersBOT, the Jaguars (+3) are a 56% chance of covering the spread, while the 43.5-point Over/Under is considered an equal 50-50 chance of hitting.

More: Predictions for Every NFL Week 2 Matchup

Best Bets for Colts vs. Jaguars

• Spread: Jaguars +3 @ -104 via FanDuel Sportsbook (56% probability) 🔥
• Moneyline: Jaguars @ +142 via FanDuel Sportsbook
• Total: Under 43.5 @ -107 via PointsBet (50% probability)

Any time you see a 🔥, you know you've found one of Dimers' best free picks today across all sports.

Our best bets are based on complex simulations and betting intelligence to bring you the best possible plays every time.

While the Colts are more likely to win the game, according to DimersBOT, betting on the Jaguars moneyline is the best option due to the edge found when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges seen here at Dimers is pivotal to being a profitable bettor in the long run.

Colts vs. Jaguars Prediction

Dimers.com's predicted final score for Indianapolis vs. Jacksonville at TIAA Bank Field in Week 2 has the Colts winning 22-20.

Click or tap on See Matchup to reveal more.

Dimers has full betting coverage of this week's Colts-Jaguars matchup in Week 2, including pregame predictions, top betting picks, and live win probabilities.

Colts vs. Jaguars Player Props

Who will score an anytime touchdown in Colts vs. Jaguars? The data is in.

Listed below are the most likely first touchdown and most likely anytime touchdown scorers for both the Colts and Jaguars, as well as player stat projections.

And you know what, we provide this information to you for FREE to help you choose the best prop picks for Sunday's game.

According to DimersBOT, Indianapolis' Jonathan Taylor is most likely to score the first touchdown in Colts vs. Jaguars.

DimersBOT gives Taylor a 21.5% chance of scoring the first TD at TIAA Bank Field, while the Colts RB is a 70.1% chance of scoring an anytime touchdown.

Scroll down for the full list of first and anytime TD scorer probabilities.

First Touchdown Scorer Probabilities

Indianapolis Colts

• Jonathan Taylor: 21.5% probability
• Parris Campbell: 7.2% probability
• Nyheim Hines: 7.0% probability
• Kylen Granson: 5.0% probability
• Ashton Dulin: 4.8% probability

Jacksonville Jaguars

• Travis Etienne: 7.4% probability
• Christian Kirk: 7.0% probability
• James Robinson: 6.6% probability
• Trevor Lawrence: 5.9% probability
• Marvin Jones: 5.3% probability

Anytime Touchdown Scorer Probabilities

Indianapolis Colts

• Jonathan Taylor: 70.1% probability
• Parris Campbell: 30.6% probability
• Nyheim Hines: 29.6% probability
• Kylen Granson: 23.0% probability
• Ashton Dulin: 21.4% probability

Jacksonville Jaguars

• Travis Etienne: 31.7% probability
• Christian Kirk: 30.6% probability
• James Robinson: 30.4% probability
• Trevor Lawrence: 26.8% probability
• Marvin Jones: 23.6% probability

Colts-Jaguars Projected Player Stats

Of the starting quarterbacks, the Colts' Matt Ryan is projected to have a big game with 284 passing yards, while the Jaguars' Trevor Lawrence is expected to throw for 244 yards.

Colts Starting QB

• Matt Ryan: 284 projected yards

Jaguars Starting QB

• Trevor Lawrence: 244 projected yards

Colts Rushing

• Jonathan Taylor: 117 projected yards
• Nyheim Hines: 19 projected yards
• Matt Ryan: 8 projected yards

Jaguars Rushing

• James Robinson: 63 projected yards
• Travis Etienne: 44 projected yards
• Trevor Lawrence: 26 projected yards

Colts Receiving

• Parris Campbell: 52 projected yards
• Ashton Dulin: 46 projected yards
• Mike Strachan: 30 projected yards
• Kylen Granson: 29 projected yards
• Nyheim Hines: 27 projected yards

Jaguars Receiving

• Christian Kirk: 64 projected yards
• Marvin Jones: 42 projected yards
• Zay Jones: 41 projected yards
• Evan Engram: 29 projected yards
• Travis Etienne: 25 projected yards

Don't forget, DimersBOT updates often, so refresh this page for the latest betting analysis ahead of Colts vs. Jaguars on Sunday September 18, 2022.

Colts vs. Jaguars 2022

The NFL Week 2 action between the Jaguars and Colts at TIAA Bank Field is scheduled to commence at 1:00PM ET.

• Who: Indianapolis Colts vs. Jacksonville Jaguars
• Date: Sunday September 18, 2022
• Time: 1:00PM ET / 10:00AM PT
• Venue: TIAA Bank Field

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What NFL games are on today?

Now you've got the 411 on Colts vs. Jaguars, see the latest betting coverage for all upcoming NFL games in Dimers' NFL Bet Hub, where you can find probabilities and odds, as well as our best bets for every single NFL matchup.

Want a pick for the Spread? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!