College Football Best Bets: Three Favorite Picks for Week 6 of the 2022 Season

We're 6-2-1 with our college football best bets over the last three weeks, but we're hungry for more wins with our trio of plays for Week 6 on Saturday. Check out what we have for you to follow for the October 8 slate. 

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Week 6 College Football Best Bets for Saturday, October 8, 2022

Ole Miss Rebels vs. Vanderbilt Commodores - 4:00PM ET

The Rebels have failed to cover in back-to-back games, with the team actually looking really disappointing in the first of those two straight-up wins. Ole Miss only beat Tulsa by eight points, despite being favored by 21 in that game. Now, Lane Kiffin's team is a big road favorite over Vanderbilt, but it's pretty hard to trust the Rebels to cover this big of a spread. 

The Commodores got smoked by Alabama last week, but they have been rather competitive the rest of the year. The offense has been especially solid outside of that meeting with the Crimson Tide, with Vanderbilt averaging 42.0 points per game against non-Alabama opponents.

The Commodores might not absolutely light it up in this one, but we think they'll score enough to cover this big of a spread at home. This Ole Miss team can run the football very effectively, but the passing game isn't nearly as explosive as it was with Matt Corral under center. That makes it hard on the Rebels to create huge separation. 

Vanderbilt hasn't won a lot of games under head coach Clark Lea, but the team is 7-6 against the spread as an underdog. The Commodores are also 5-4 ATS versus SEC opponents in that span. 

BET: Vanderbilt +17 at -110 at DraftKings Sportsbook

🏈 Ole Miss vs. Vanderbilt Predictions
📈 Betting preview: Ole Miss vs. Vanderbilt

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North Carolina Tar Heels vs. Miami Hurricanes - 4:00PM ET

This Miami team hasn't lived up to expectations this season, but Mario Cristobal and Co. have to feel pretty good about their chances on Saturday. North Carolina might have an explosive offense, but quarterback Drake Maye and the Tar Heels haven't faced many great defenses. And in their only meeting with a good one, they ended up losing to Notre Dame. 

The Hurricanes defense is giving up just 20.5 points per game this season, and Miami has an elite rushing defense. That should help slow down North Carolina, which does blend the run and pass — even if most of the explosive plays in the offense do come from Maye's arm. The Hurricanes defense should ultimately be the difference maker in this one, as we trust them to get the Tar Heels off the field enough to cover this small spread. 

Of course, it might be hard to envision quarterback Tyler Van Dyke playing well after his slow start to the year, but a meeting with the Tar Heels defense is a perfect cure for that. North Carolina is allowed 33.6 points per game this season and Miami should be able to score against this defense. 

Over the last three seasons, the Tar Heels also happen to be 0-8 ATS when coming off a home win over an ACC opponent. That's tough to ignore, as it shows a consistent trend with Mack Brown's team. 

BET: Miami -3 at -125 at DraftKings Sportsbook

🏈 North Carolina vs. Miami Predictions
📈 Betting preview: North Carolina vs. Miami

South Carolina Gamecocks vs. Kentucky Wildcats - 7:30PM ET

Kentucky is coming off of a tough loss to Ole Miss last week, but the Wildcats can't afford to sit around and sulk about it. They have a tough matchup with the Gamecocks on Saturday and this is a game in which we actually like South Carolina to keep it close. 

Oddly enough, the Wildcats are 9-18 ATS when coming off a road loss under Mark Stoops and the team is also 6-19 ATS when facing teams that complete at least 62% of their passes in that time. While Spencer Rattler has had an up-and-down ride in his first year with South Carolina, he is completely 64.9% of his passes. There might be a mistake or two incoming from the former Oklahoma quarterback, but Rattler is talented enough to make an impact in this game and help his team pull off a stunning performance. 

It also helps that the Gamecocks seemingly know how to slow down the Wildcats offense. Last year, South Carolina held Kentucky to only 16 points in a close loss at home. If the Gamecocks defense can similarly lock in here, you'd have to think that Rattler and this offense can do enough to lose by less than a touchdown. 

BET: South Carolina +7 at -130 at DraftKings Sportsbook

🏈 South Carolina vs. Kentucky Predictions
📈 Betting preview: South Carolina vs. Kentucky