College Football Best Bets: Five Favorite Picks for Week 8 of the 2022 Season

We went 3-0 with our college football best bets last week, so make sure you check out what we have for Saturday, October 22. We have five picks for this weekend, which should show you how much we're loving the board.

We also have a few late-night bets for some of our night owls. There's nothing quite like staying up and betting on the Pac-12 or Mountain West, so we're making sure we have you covered all throughout the night. 

If you haven't already, you should consider signing up for DraftKings ➡️ here ⬅️ as you can turn a $5 pre-game moneyline bet on any game into a free $200 if your team wins. 

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RELATED: College Football Bet Hub 

Week 8 College Football Best Bets 

Ole Miss Rebels vs. LSU Tigers - 3:30PM ET

The weirdest line of the day sees an average LSU team as a small home favorite over undefeated Ole Miss. This game absolutely screams "trap" and we're aligning ourselves with the oddsmakers because of that. Geaux Tigers! 

LSU's offense did click in a big way against Florida last week, with quarterback Jayden Daniels throwing for 349 yards and three touchdowns in a huge road win. He also added another 44 yards and three scores on the ground, and his dual-threat ability gives LSU a great shot at matching the explosiveness of Lane Kiffin's offense. Daniels could actually be capable of outdueling Jaxson Dart, who is a little unproven as a passer. 

The home team has also covered in eight of the last nine meetings between these teams. 

BET: LSU -2 at -110 at DraftKings Sportsbook

🏈 Ole Miss vs. LSU Predictions
📈 Betting preview: Ole Miss vs. LSU

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Watch CFB Prop or Chop to see the Props you absolutely must bet on Saturday!

Vanderbilt Commodores vs. Missouri Tigers - 4:00PM ET

It's very surprising to see that a lousy Missouri team is laying two touchdowns against anybody. The fact that the opponent is another SEC school makes it downright shocking. While the Commodores aren't the greatest team in the world, they have been more competitive than expected this season and they can absolutely find a way to keep this game from getting out of hand. 

Vanderbilt will be excited to get a crack at a reasonable opponent after losses to Alabama, Ole Miss and Georgia over the last three weeks. The Commodores have the second-worst scoring defense in all of college football, but they might not look quite as miserable against a Tigers team that only scores 25.2 points per game. 

The Commodores also have a decent offense and should be able to go back and forth with their opponents in this one. That's what makes it so hard to believe that this will turn into a legitimate blowout. 

BET: Vanderbilt +14 at -110 at DraftKings Sportsbook

🏈 Vanderbilt vs. Missouri Predictions
📈 Betting preview: Vanderbilt vs. Missouri

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Minnesota Golden Gophers vs. Penn State Nittany Lions - 7:30PM ET

Over the last three seasons, the Golden Gophers are 7-4 straight-up and 8-3 ATS when playing on the road. They're also 6-5 SU and 7-4 ATS as underdogs in that time. On top of that, while it hasn't happened very often, the team is also 2-0 ATS when coming off back-to-back losses against Big Ten opponents. With that in mind, we expect PJ Fleck to have no trouble getting his team motivated in this one. 

Minnesota also happens to have the fourth-best scoring defense in all of college football, as this team is giving up only 11.7 points per game. We expect the Golden Gophers to give Sean Clifford some trouble and make this a very tight game — and perhaps even steal a win on the road. 

BET: Minnesota +5 at -110 at DraftKings Sportsbook

🏈 Minnesota vs. Penn State Predictions
📈 Betting preview: Minnesota vs. Penn State

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San Diego State Aztecs vs. Nevada Wolf Pack - 10:30PM ET

Nevada's season has been a trainwreck thus far, but the Wolf Pack really should be able to keep it within one score against an Aztecs team that has only covered in one game this entire season. Nevada has actually covered in four consecutive meetings between these two, and it's also worth noting that the Aztecs are just 1-3-1 ATS as road favorite under Brady Hoke. 

While the Wolf Pack no longer have an explosive passing game with Carson Strong now an NFL free agent, the Aztecs are averaging only 18.5 points per game this season. Only 12 teams in all of college football are averaging less than that, and it's hard to win games by over a touchdown when you're not scoring them yourself. 

BET: Nevada +7 at -110 at DraftKings Sportsbook

🏈 San Diego State vs. Nevada Predictions
📈 Betting preview: San Diego State vs. Nevada

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Washington Huskies vs. California Golden Bears - 10:30PM ET

California is coming off an embarrassing loss as a 14.5-point favorite against Colorado last week, but the team now hosts a Washington squad that hasn't looked all that great recently. The Huskies have a good record and were dynamite to start the year, but they have failed to cover in each of their last three games. 

Washington is just 2-9 ATS when coming off a Pac-12 game since the start of last season, so this Huskies team hasn't exactly handled its business in conference play lately. Meanwhile, the Golden Bears are 22-10 ATS when playing as underdogs since Justin Wilcox became the team's head coach. They're also 9-3 ATS as home underdogs in that span. 

This might be a game that ends up being hard to watch, but we think Cal can keep it close. 

BET: California +7.5 at -110 at DraftKings Sportsbook

🏈 Washington vs. California Predictions
📈 Betting preview: Washington vs. California

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