College Basketball and March Madness Picks Today: Friday's Best Bets Include Liberty vs. Oregon Play [3/21/2025]

College basketball betting is back for another attractive slate on 3/21, and we're here to bring you our top picks for Friday's NCAAM action, with our model working hard to find bets in the March Madness tournament and elsewhere.

Today's college basketball best bets come from a range of matchups, including the Liberty vs. Oregon game at 10:10PM ET, with this article updated throughout the day to highlight the most attractive upcoming games.

Featuring a standout moneyline play at 10:10PM ET, these picks are powered by data-driven simulations and machine learning.

For unlimited access to everything Dimers has to offer on Friday, March 21, 2025—including our complete set of March Madness picks and best bets—check out Dimers Pro.

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List of College Basketball Picks Tonight [3/21, Updated: 10:02PM ET]

After digging deep into the numbers and conducting thousands of simulations, our independent predictive analytics model has figured out the best college basketball bet for Friday, March 21, 2025.

This is the only pick available for free users currently, with our full suite of college basketballpredictions reserved for Dimers Pro users.

Oregon ML (-295)

• Edge: 2.9%
• Probability: 77.6%
• Matchup: Liberty vs. Oregon (10:10PM ET, Friday)

Our model has pinpointed the next college basketball betting opportunity tonight, which comes in the Liberty vs. Oregon March Madness game. We recommend a bet on the Oregon ML at -295 odds, offering an edge of 2.9%.

Oregon ML vs. Liberty

-295

Bet $25
Payout $33.48Bet $25, Payout $33.48

NCAAM Best Bets: Friday, 3/21/2025

As of 10:02PM ET, here are the next college basketball bets recommended by our model:

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Subscribing to Dimers Pro grants you unlimited access to today's best bets across all sports, powered by our advanced model.

Among Friday's college basketball picks is a -102 spread play with an edge of 4.5%.

Join Dimers Pro now to access these picks, along with a comprehensive range of props, trends and parlays for March 21, 2025.

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List of Upcoming College Basketball Games To Bet On

• Liberty vs. Oregon (10:10PM ET, Friday)
• Dayton vs. Chattanooga (11:30AM ET, Saturday)
• McNeese State vs. Purdue (12:10PM ET, Saturday)
• Bradley vs. George Mason (2:00PM ET, Saturday)
• Arkansas vs. St. John's (2:40PM ET, Saturday)
• Michigan vs. Texas A&M (5:15PM ET, Saturday)
• Drake vs. Texas Tech (6:10PM ET, Saturday)
• Creighton vs. Auburn (7:10PM ET, Saturday)
• BYU vs. Wisconsin (7:45PM ET, Saturday)
• Gonzaga vs. Houston (8:40PM ET, Saturday)

More About CBB

This article is part of our college basketball player props and college basketball best bets series.

For more NCAAB betting content, we have college basketball betting news and the latest March Madness odds and predictions.

Conclusion

This article, enhanced by AI and automation, aims to deliver accurate college basketball insights quickly, with human oversight ensuring high editorial quality. Our predictions are rooted in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.