Guardians vs. Cardinals Prediction: Guardians Predicted to Win After New Data Released for Saturday's MLB Game [9/21/2024]

The St. Louis Cardinals will take on the Cleveland Guardians, in what is expected to be a close MLB game, at Busch Stadium on Saturday, starting at 7:15PM ET.

The Cardinals will have Miles Mikolas (8-11, 5.49 ERA) as their starting pitcher, while the Guardians have opted for Matthew Boyd (2-1, 2.52 ERA).

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Guardians as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's Guardians-Cardinals game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Guardians are more likely to win, while the Cardinals have a lower chance of victory."

Guardians vs. Cardinals Game-Day Updates and Essential Details

Saturday's MLB action between the Cardinals and Guardians at Busch Stadium is scheduled to start at 7:15PM ET.

• Who: Cleveland Guardians vs. St. Louis Cardinals
• Date: Saturday, September 21, 2024
• Time: 7:15PM ET/4:15PM PT
• Venue: Busch Stadium
• Tickets: Get tickets for the game on Ticketmaster
• Merchandise: Buy Cardinals and Guardians gear at Fanatics
• Live Stream: Watch the game on FuboTV

Dimers.com's in-depth preview of Saturday's Guardians vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Guardians vs. Cardinals Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and statistical analysis, we have simulated the result of Saturday's MLB game between the Guardians and Cardinals 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Guardians a 54% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 59% chance of covering the run line, while the 7.5-run over/under has a 58% chance of going over.

Guardians vs. Cardinals Odds [9/21/2024]

We have sourced the best betting odds in America for this game, which are listed here:

Bet Type	Guardians	Cardinals
Run Line	-1.5 (+135)	+1.5 (-155)
Moneyline	-130	+110
Total	o7.5 (-108)	u7.5 (-102)

All odds are correct at the time of publication and are subject to change.

Guardians vs. Cardinals Picks

Our model's strongest edge in today's Guardians vs. Cardinals matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks for every game throughout the season.

Full access to our picks, including this one, is available via Dimers Pro.

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Conclusion

We predict the Guardians, with a 54% win probability, will likely beat the Cardinals on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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