Guardians vs. Pirates Prediction: Pittsburgh Predicted to Win Sunday's MLB Matchup [4/20/2025]

The Pittsburgh Pirates will face the Cleveland Guardians, in what is expected to be a tight MLB game, at PNC Park on Sunday, commencing at 1:35PM ET.

Mitch Keller (1-2, 4.30 ERA) will start on the mound for the Pirates, while the Guardians have opted for Logan Allen (1-1, 2.30 ERA).

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Pirates as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Cleveland-Pittsburgh game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Pirates with a win probability of 51%, while the Guardians have 49%."

For expanded analysis of Sunday's matchup, including best bets and picks, visit our interactive Guardians vs. Pirates predictions page.

Get 20% off Dimers Pro With Code 20BASEBALL

Get Dimers Pro

Guardians vs. Guardians Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the outcome of Sunday's MLB matchup between the Guardians and Pirates 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Pirates a 51% chance of defeating the Guardians.

According to our model, the Pirates (+1.5) have a 64% chance of covering the run line, while the over/under total of 8 runs has a 52% chance of staying under.

Pre-Game Probabilities

Last Updated: 6:28PM, Apr 20

Moneyline

Over / Under

Run Line

Guardians

Win %

49%

51%

+105

-117

Get the best bets with Dimers Pro

See Matchup

Get Dimers Pro

Pirates

Guardians CLE

+105

Win %

49%

51%

See Matchup

Pirates PIT

-117

Logan Allen 1-1, 2.30 ERA

Mitch Keller 1-2, 4.30 ERA

Get the best bets with Dimers Pro

Get Dimers Pro

Guardians vs. Pirates Odds [4/20/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Guardians vs. Pirates Picks and Best Bets

Our model's biggest edge in today's Guardians vs. Pirates matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Unlock Every Guardians-Pirates Pick

Get Dimers Pro

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Guardians vs. Pirates Game-Day Updates and Essential Details

Sunday's MLB action between the Pirates and Guardians at PNC Park is scheduled to start at 1:35PM ET.

• Who: Cleveland Guardians vs. Pittsburgh Pirates
• Date: Sunday, April 20, 2025
• Time: 1:35PM ET/10:35AM PT
• Venue: PNC Park

Dimers.com's in-depth preview of Sunday's Guardians vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any Cleveland vs. Pittsburgh picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Pirates, with a 51% win probability, will likely beat the Guardians on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay informed with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest probabilities for the World Series, American League, National League and each division.