Guardians vs. Pirates Prediction: Pittsburgh Predicted to Win Saturday's MLB Matchup [4/19/2025]

MLB action continues on Saturday at 4:05PM ET as the Cleveland Guardians take on the Pittsburgh Pirates at PNC Park.

Paul Skenes (2-1, 2.96 ERA) will be on the bump for the Pirates, while the Guardians have opted for Ben Lively (0-2, 4.87 ERA).

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects the Pirates as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's Cleveland-Pittsburgh game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Pirates are more likely to win, while the Guardians have a lower chance of victory."

For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Guardians vs. Pirates predictions page.

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Guardians vs. Guardians Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the outcome of Saturday's MLB game between the Guardians and Pirates 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Pirates a 63% chance of defeating the Guardians.

According to our model, the Guardians (+1.5) have a 58% chance of covering the run line, while the over/under total of 8 runs has a 55% chance of staying under.

Pre-Game Probabilities

Last Updated: 8:28PM, Apr 19

Moneyline

Over / Under

Run Line

Guardians

Win %

38%

62%

+162

-180

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Pirates

Guardians CLE

+162

Win %

38%

62%

See Matchup

Pirates PIT

-180

Ben Lively 0-2, 4.87 ERA

Paul Skenes 2-1, 2.96 ERA

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Guardians vs. Pirates Odds [4/19/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Pirates Picks and Best Bets

Our model's biggest edge in today's Guardians vs. Pirates matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Guardians vs. Pirates Game-Day Updates and Essential Details

Saturday's MLB matchup between the Pirates and Guardians at PNC Park is scheduled to start at 4:05PM ET.

• Who: Cleveland Guardians vs. Pittsburgh Pirates
• Date: Saturday, April 19, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: PNC Park

Dimers.com's comprehensive preview of Saturday's Guardians vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any Cleveland vs. Pittsburgh picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Pirates, with a 63% win probability, will likely beat the Guardians on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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