Guardians vs. Pirates Prediction: Cleveland Predicted to Win Friday's MLB Matchup [4/18/2025]

The Pittsburgh Pirates and Cleveland Guardians will lock horns in MLB action at PNC Park on Friday, starting at 6:40PM ET.

The Pirates will have Carmen Mlodzinski (1-2, 6.23 ERA) as their starting pitcher, while the Guardians are going with Luis L. Ortiz (1-2, 6.06 ERA).

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Guardians as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Cleveland-Pittsburgh game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Guardians' chance of winning is 54%, while the Pirates' is 46%."

For further insights into Friday's matchup, including best bets and picks, visit our interactive Guardians vs. Pirates predictions page.

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Guardians vs. Guardians Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and statistical analysis, we have simulated the result of Friday's MLB matchup between the Guardians and Pirates 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Guardians a 54% chance of defeating the Pirates.

According to our model, the Pirates (+1.5) have a 60% chance of covering the run line, while the over/under total of 8.5 runs has a 51% chance of staying under.

Pre-Game Probabilities

Last Updated: 10:28PM, Apr 18

Moneyline

Over / Under

Run Line

Guardians

Win %

54%

46%

-125

+114

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See Matchup

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Pirates

Guardians CLE

-125

Win %

54%

46%

See Matchup

Pirates PIT

+114

Luis Ortiz 1-2, 6.06 ERA

Carmen Mlodzinski 1-2, 6.23 ERA

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Guardians vs. Pirates Odds [4/18/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Pirates Picks and Best Bets

Our model's strongest edge in today's Guardians vs. Pirates matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Guardians vs. Pirates Game-Day Updates and Essential Details

Friday's MLB matchup between the Pirates and Guardians at PNC Park is scheduled to begin at 6:40PM ET.

• Who: Cleveland Guardians vs. Pittsburgh Pirates
• Date: Friday, April 18, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: PNC Park

Dimers.com's in-depth preview of Friday's Guardians vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any Cleveland vs. Pittsburgh picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Guardians, with a 54% win probability, will likely beat the Pirates on Friday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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