Guardians vs. Royals Prediction: Kansas City Predicted to Win MLB Opening Day Matchup [3/27/2025]

The Kansas City Royals will take on the Cleveland Guardians on Opening Day of the 2022 MLB season at Kauffman Stadium on Thursday, starting at 4:10PM ET.

Cole Ragans (0-0, 0.00 ERA) will start for the Royals, while the Guardians have opted for Ben Lively (0-0, 0.00 ERA).

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Royals as the most likely winner of today's game.

"Using the latest data, our experts simulated Thursday's Cleveland-Kansas City game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast the Royals with a win probability of 59% and the Guardians with 41%."

For further insights into Thursday's matchup, including best bets and picks, visit our interactive Guardians vs. Royals predictions page.

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Guardians vs. Guardians Prediction: Who Will Win on MLB Opening Day?

Using innovative machine learning and data analysis, we have simulated the outcome of Thursday's MLB game between the Guardians and Royals 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Royals a 59% chance of defeating the Guardians.

According to our model, the Guardians (+1.5) have a 60% chance of covering the run line, while the over/under total of 8.5 runs has a 57% chance of staying under.

Pre-Game Probabilities

Last Updated: 8:28PM, Mar 27

Moneyline

Over / Under

Run Line

Guardians

Win %

41%

59%

+150

-166

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Royals

Guardians CLE

+150

Win %

41%

59%

See Matchup

Royals KC

-166

Ben Lively 0-0, 0.00 ERA

Cole Ragans 0-0, 0.00 ERA

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Guardians vs. Royals Odds [3/27/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Royals Picks and Best Bets

Our model's biggest edge in today's Guardians vs. Royals matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free MLB Picks

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Guardians vs. Royals Game-Day Updates and Essential Details

Thursday's MLB action between the Royals and Guardians at Kauffman Stadium is scheduled to begin at 4:10PM ET.

• Who: Cleveland Guardians vs. Kansas City Royals
• Date: Thursday, March 27, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: Kauffman Stadium

Dimers.com's in-depth preview of Thursday's Guardians vs. Royals matchup includes our prediction, picks and the latest betting odds.

Before making any Cleveland vs. Kansas City picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Royals, with a 59% win probability, will likely beat the Guardians on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Royals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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