Guardians vs. Orioles Prediction: Baltimore Predicted to Win Wednesday's MLB Matchup [4/16/2025]

The Baltimore Orioles will square off with the Cleveland Guardians in MLB action at Oriole Park at Camden Yards on Wednesday, beginning at 6:35PM ET.

The Orioles will send Dean Kremer (1-2, 8.16 ERA) to the mound, while the Guardians are going with Gavin Williams (1-0, 3.46 ERA).

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Orioles as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Cleveland-Baltimore game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Orioles' chance of winning at 53%, with the Guardians at 47%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Guardians vs. Orioles predictions page.

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Guardians vs. Guardians Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Wednesday's MLB game between the Guardians and Orioles 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Orioles a 53% chance of defeating the Guardians.

According to our model, the Guardians (+1.5) have a 64% chance of covering the run line, while the 8-run over/under has a 55% chance of going over.

Pre-Game Probabilities

Last Updated: 10:28PM, Apr 16

Moneyline

Over / Under

Run Line

Guardians

Win %

47%

53%

+110

-125

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See Matchup

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Orioles

Guardians CLE

+110

Win %

47%

53%

See Matchup

Orioles BAL

-125

Gavin Williams 1-0, 3.46 ERA

Dean Kremer 1-2, 8.16 ERA

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Guardians vs. Orioles Odds [4/16/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Orioles Picks and Best Bets

Our model's biggest edge in today's Guardians vs. Orioles matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

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Guardians vs. Orioles Game-Day Updates and Essential Details

Wednesday's MLB game between the Orioles and Guardians at Oriole Park at Camden Yards is scheduled to commence at 6:35PM ET.

• Who: Cleveland Guardians vs. Baltimore Orioles
• Date: Wednesday, April 16, 2025
• Time: 6:35PM ET/3:35PM PT
• Venue: Oriole Park at Camden Yards

Dimers.com's in-depth preview of Wednesday's Guardians vs. Orioles matchup includes our prediction, picks and the latest betting odds.

Before making any Cleveland vs. Baltimore picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Orioles, with a 53% win probability, will likely beat the Guardians on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Orioles insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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