Guardians vs. Orioles Prediction: Close Contest Projected After New Data Released for Thursday's MLB Matchup [4/17/2025]

MLB action continues on Thursday at 6:35PM ET as the Cleveland Guardians take on the Baltimore Orioles at Oriole Park at Camden Yards.

The Orioles will send Tomoyuki Sugano (1-1, 3.86 ERA) to the mound, while the Guardians are going with Tanner Bibee (1-1, 4.40 ERA).

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts an equal chance for both the Orioles and Guardians to win today's game.

"Using the latest data, our experts simulated Thursday's Cleveland-Baltimore game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Based on the latest updates and extensive data, we predict a 50-50 chance for both the Orioles and Guardians, making it a highly competitive matchup."

For expanded analysis of Thursday's matchup, including best bets and picks, visit our interactive Guardians vs. Orioles predictions page.

Get 20% off Dimers Pro With Code 20BASEBALL

Get Dimers Pro

Guardians vs. Guardians Prediction: Who Will Win?

Using powerful machine learning and statistical analysis, we have simulated the result of Thursday's MLB game between the Guardians and Orioles 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently can't split the two teams, giving both the Guardians and Orioles a 50% chance of winning the game.

According to our model, the 8-run over/under has a 58% chance of going over.

Pre-Game Probabilities

Last Updated: 10:27PM, Apr 17

Moneyline

Over / Under

Guardians

Win %

50%

50%

+120

-125

Get the best bets with Dimers Pro

See Matchup

Get Dimers Pro

Orioles

Guardians CLE

+120

Win %

50%

50%

See Matchup

Orioles BAL

-125

Tanner Bibee 1-1, 4.40 ERA

Tomoyuki Sugano 1-1, 3.86 ERA

Get the best bets with Dimers Pro

Get Dimers Pro

Guardians vs. Orioles Odds [4/17/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Guardians vs. Orioles Picks and Best Bets

Our model's strongest edge in today's Guardians vs. Orioles matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Unlock Every Guardians-Orioles Pick

Get Dimers Pro

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Guardians vs. Orioles Game-Day Updates and Essential Details

Thursday's MLB action between the Orioles and Guardians at Oriole Park at Camden Yards is scheduled to begin at 6:35PM ET.

• Who: Cleveland Guardians vs. Baltimore Orioles
• Date: Thursday, April 17, 2025
• Time: 6:35PM ET/3:35PM PT
• Venue: Oriole Park at Camden Yards

Dimers.com's comprehensive preview of Thursday's Guardians vs. Orioles matchup includes our prediction, picks and the latest betting odds.

Before making any Cleveland vs. Baltimore picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict a close game between the Guardians and Orioles on Thursday, with each team having a 50% chance of winning.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Orioles insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay up-to-date with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest projections for the World Series, American League, National League and each division.