Clemson vs. South Carolina CFB Predictions and Odds - Nov 27, 2021

South Carolina squares off with the favored Clemson in College Football Week 13 action at Williams-Brice Stadium on Saturday, commencing at 7:30 PM EST.

Dimers' top betting picks for Clemson vs. South Carolina, as well as game predictions and best odds, are featured below.

Who will win Clemson vs. South Carolina?

Using state-of-the-art computer power and data, Dimers.com has simulated Saturday's Clemson-South Carolina NCAA Football matchup 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, gives Clemson an 81% chance of winning against South Carolina.

MORE: Clemson vs. South Carolina Simulated 10,000 Times

Clemson vs. South Carolina Point Spread, Moneyline and Over/Under

South Carolina is the +11.5 underdog against Clemson, with -110 at Caesars Sportsbook the best odds available.

For the favored Clemson (-11.5) to cover the spread, FanDuel Sportsbook has the best odds on offer at -106.

DraftKings Sportsbook has the best moneyline odds for South Carolina at +350, which means you can bet $100 to profit $350, earning a total payout of $450, if it wins.

Elsewhere, PointsBet has the best moneyline odds for Clemson at -450, where you can risk $450 to win $100, for a total payout of $550, if it comes out on top.

The Over/Under is set at 42.5 with FanDuel Sportsbook, which has the best odds for the Over at -108, while Caesars Sportsbook has the best odds for the Under at -110.

As always, check out all the sportsbooks available in your state for the best College Football odds and lines.

According to DimersBOT, the bookmakers have got it right and both Clemson and South Carolina are a 50% chance of covering the spread, while the 42.5-point Over/Under is a 58% chance of going Under.

MORE: Today's Best Bets for All Major College Sports

Best Bets for Clemson vs. South Carolina

• Spread: Clemson -11.5 at -106 with FanDuel Sportsbook (50% probability)
• Moneyline: Clemson Win at -450 with PointsBet (81% probability)
• Over/Under: Under 42.5 at -110 with Caesars Sportsbook (58% probability) 🔥

Any time you see a 🔥, you know it's one of our best free picks of the day across all major pro and college sports.

Clemson vs. South Carolina Score Prediction

Dimers.com's predicted final score for Clemson vs. South Carolina at Williams-Brice Stadium on Saturday has Clemson winning 28-16.

Use our interactive widget below to see the current Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup to reveal more.

Dimers has full betting coverage of this week's Clemson-South Carolina matchup, including pre-game predictions, computer picks, and live win probabilities.

Remember, DimersBOT updates often, so refresh this article for the latest betting insights before Clemson vs. South Carolina on Saturday November 27, 2021.

Clemson vs. South Carolina 2021 CFB Game Info

When does South Carolina play Clemson in College Football?

• Date: Saturday November 27, 2021
• Time: 7:30 PM EST / 4:30 PM PST
• Venue: Williams-Brice Stadium

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What CFB games are on this week?

Now you've got the 411 on Clemson vs. South Carolina, get the latest betting predictions for all upcoming NCAA Football games in Dimers' College Football Bet Hub. There you can find probabilities and odds, plus our best bets for every single CFB matchup.

Want a pick for the Spread? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!