Clemson vs. Notre Dame CFB Prediction and Odds - Nov 5, 2022

Notre Dame and Clemson clash in College Football action at Notre Dame Stadium on Saturday, with kickoff at 7:30PM ET.

Dimers' free betting picks for Clemson vs. Notre Dame, as well as our score prediction and betting odds, are featured in this article.

Who will win Clemson vs. Notre Dame?

Using cutting-edge computer power and data, Dimers.com has simulated Clemson vs. Notre Dame 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, gives Clemson a 56% chance of beating Notre Dame.

More: Full Betting Guide for Clemson vs. Notre Dame

Clemson vs. Notre Dame Odds

• Spread: Notre Dame +3.5 (-105), Clemson -3.5 (-110)
• Moneyline: Notre Dame +162, Clemson -180
• Total: Over/Under 43.5 (-110/-110)

Point Spread, Moneyline and Over/Under

Notre Dame is the +3.5 underdog against Clemson, with -105 at FanDuel Sportsbook the best odds currently available.

For the favored Clemson (-3.5) to cover the spread, Caesars Sportsbook has the best odds currently on offer at -110.

FanDuel Sportsbook currently has the best moneyline odds for Notre Dame at +162, which means you can bet $100 to profit $162, earning a total payout of $262, if it wins.

Meanwhile, DraftKings Sportsbook currently has the best moneyline odds for Clemson at -180, where you can risk $180 to win $100, for a total payout of $280, if it comes out on top.

The Over/Under for total points scored is set at 43.5 with Caesars Sportsbook, which currently has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, check out all of the online sportsbooks that are available in your state for the best College Football odds and lines.

According to DimersBOT, Notre Dame (+3.5) is a 58% chance of covering the spread, while the 43.5-point Over/Under is a 57% chance of going Over.

More: Free Prop Picks

Best Bets for Clemson vs. Notre Dame

• Spread: Notre Dame +3.5 @ -105 via FanDuel Sportsbook (58% probability) 🔥
• Moneyline: Notre Dame @ +162 via FanDuel Sportsbook (6.1% edge) 🔥
• Total: Over 43.5 @ -110 via Caesars Sportsbook (57% probability) 🔥

When you see a 🔥, that means you've found one of our best bets today across all sports.

Dimers' best bets are based on world-class simulations and wagering expertise to help you make more informed decisions with your state's legal sportsbooks.

While Clemson is more likely to win the game, according to DimersBOT, taking Notre Dame moneyline is the best option due to the 6.1% edge found when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges seen here at Dimers is pivotal to achieving long-term profitability as a bettor.

Clemson vs. Notre Dame Prediction

Dimers.com's predicted final score for Clemson vs. Notre Dame at Notre Dame Stadium this Saturday has Clemson winning 24-22.

Click or tap on See Matchup for more.

Dimers has full betting coverage of this week's Clemson-Notre Dame matchup, including pregame predictions, free betting picks, and live win probabilities.

Remember, DimersBOT updates often, so check this page for the latest betting analysis before Clemson vs. Notre Dame on Saturday November 5, 2022.

Clemson vs. Notre Dame 2022 CFB Game Info

Saturday's action between Notre Dame and Clemson in College Football at Notre Dame Stadium is scheduled to begin at 7:30PM ET.

• Who: Clemson vs. Notre Dame
• Date: Saturday November 5, 2022
• Time: 7:30PM ET / 4:30PM PT
• Venue: Notre Dame Stadium

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What CFB games are on this week?

Now you've got the 411 on Clemson vs. Notre Dame, check out the latest betting analysis for all upcoming NCAA Football games in our College Football Bet Hub, where you can find probabilities and odds, and our best bets for each and every CFB matchup.

Want a pick for the Spread? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!