Clemson vs. Iowa State CFB Predictions and Odds - Dec 29, 2021

Updated: Dec 21, 2023, 3:36AM | First published: Dec 8, 2021, 2:34AM

Written by Kevin Hansen, Senior Sports Analyst

Clemson vs. Iowa State CFB Predictions and Odds - Dec 29, 2021

Iowa State and Clemson lock horns in the 2021 Cheez-It Bowl at Camping World Stadium on Wednesday, with kickoff at 5:45PM EST.

Dimers' top betting picks for Clemson vs. Iowa State, plus our score prediction and best odds, are featured below.

Who will win the 2021 Cheez-It Bowl?

Using cutting-edge machine learning and data, Dimers.com has simulated the 2021 Cheez-It Bowl 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, can't split the two teams, giving both Clemson and Iowa State a 50% chance of winning the game.

MORE: Clemson vs. Iowa State Simulated 10,000 Times

Point Spread, Moneyline and Over/Under

Iowa State is the +1 underdog against Clemson, with -105 at FanDuel Sportsbook the best odds available.

For the favored Clemson (-1) to cover the spread, FanDuel Sportsbook also has the best odds on the market at -115.

BetMGM has the best moneyline odds for Iowa State at +105, which means you can throw down $100 to profit $105, earning a total payout of $205, if it wins.

Elsewhere, PointsBet has the best moneyline odds for Clemson at -120, where you can risk $120 to win $100, for a total payout of $220, if it comes out on top.

The Over/Under sits at 44 with FanDuel Sportsbook, which has the best odds for the Over at -108, while DraftKings Sportsbook has the best odds for the Under at -110.

As always, make sure you check all the legal sportbooks available in your state for the best College Football odds and lines.

According to DimersBOT, Iowa State (+1) is a 54% chance of covering the spread, while the Over/Under total of 44 points is considered an equal 50-50 chance of hitting.

MORE: Predictions for Every College Football Game

Best Bets for Clemson vs. Iowa State

Spread: Iowa State +1 at -105 with FanDuel Sportsbook (54% probability) 🔥
Moneyline: Iowa State Win at +105 with BetMGM (50% probability)
Over/Under: Over 44 at -108 with FanDuel Sportsbook (50% probability)

When you see a 🔥, that means you've found one of Dimers' best bets of the day across all major pro and college sports.

Cheez-It Bowl Score Prediction

Dimers.com's predicted score for Clemson vs. Iowa State at Camping World Stadium on Wednesday is Clemson 22-22 Iowa State.

While there is no way for a College Football game to end in a tie, our prediction of 22-22 is based on each team's average score after 10,000 simulations by DimersBOT.

Use our dynamic widget below to see the latest Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup for more.

Dimers has full betting coverage of this week's Clemson-Iowa State matchup, including pre-game predictions, best betting picks, and live scores.

Don't forget, DimersBOT updates regularly, so refresh this article for any changes to our betting insights before Clemson vs. Iowa State on Wednesday December 29, 2021.

Get a Risk-Free Bet for Clemson vs. Iowa State

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All you need to do is click or tap on this exclusive FanDuel Sportsbook link and create an account – it's easy and takes less than 2 minutes.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Clemson vs. Iowa State 2021 CFB Game Info

When does Iowa State play Clemson in College Football?

Date: Wednesday December 29, 2021
Time: 5:45PM EST / 2:45PM PST
Venue: Camping World Stadium

Want to join an online sportsbook and start betting on College Football? We've listed the best available welcome offers in each legal betting state.

College Football Bowl Matchups 2021-22

Bowl season is here, baby, and Clemson and Iowa State aren't the only two CFB teams you can bet on today.

DimersBOT never stops and we've got picks and top bets for every single NCAA Football bowl game below.

Not only do we provide with you quality CFB predictions, but we also have recommended bets for the Spread, Over/Under and Moneyline this postseason.

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College Football Playoff National Championship

Written by

Kevin Hansen

Senior Sports Analyst

Kevin Hansen specializes in NFL, NBA, MLB, and NHL content, using data-driven insights for sports betting. He provides simple, actionable betting tips to help bettors find an edge and pick winners.