Reds vs. Marlins Prediction: Cincinnati Predicted to Win Monday's MLB Matchup [4/21/2025]

The Miami Marlins will square off with the Cincinnati Reds in MLB action at loanDepot park on Monday, beginning at 6:40PM ET.

Max Meyer (1-2, 2.62 ERA) will be on the bump for the Marlins, while the Reds are going with Nick Lodolo (2-1, 2.31 ERA).

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Reds as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's Cincinnati-Miami game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Reds are likely to win, with a probability of 53%, compared to the Marlins' 47%."

For a closer look at Monday's matchup, including best bets and picks, visit our interactive Reds vs. Marlins predictions page.

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Reds vs. Reds Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the outcome of Monday's MLB matchup between the Reds and Marlins 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Reds a 53% chance of beating the Marlins.

According to our model, the Marlins (+1.5) have a 60% chance of covering the run line, while the 8-run over/under has a 55% chance of staying under.

Pre-Game Probabilities

Last Updated: 10:29PM, Apr 21

Moneyline

Over / Under

Run Line

Reds

Win %

53%

47%

-115

+102

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Marlins

Reds CIN

-115

Win %

53%

47%

See Matchup

Marlins MIA

+102

Nick Lodolo 2-1, 2.31 ERA

Max Meyer 1-2, 2.63 ERA

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Reds vs. Marlins Odds [4/21/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Reds vs. Marlins Picks and Best Bets

Our model's strongest edge in today's Reds vs. Marlins matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Reds vs. Marlins Game-Day Updates and Essential Details

Monday's MLB matchup between the Marlins and Reds at loanDepot park is scheduled to begin at 6:40PM ET.

• Who: Cincinnati Reds vs. Miami Marlins
• Date: Monday, April 21, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: loanDepot park

Dimers.com's full preview of Monday's Reds vs. Marlins matchup includes our prediction, picks and the latest betting odds.

Before making any Cincinnati vs. Miami picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Reds, with a 53% win probability, will likely beat the Marlins on Monday.

AI and automation have enhanced this article to quickly deliver accurate Reds vs. Marlins insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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