White Sox vs. Guardians Prediction: Cleveland Predicted to Win Wednesday's MLB Matchup [4/9/2025]

The Cleveland Guardians will take on the Chicago White Sox in MLB action at Progressive Field on Wednesday, commencing at 6:10PM ET.

Logan Allen (0-1, 6.75 ERA) will start for the Guardians, while the White Sox have opted for Sean Burke (1-1, 5.23 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Guardians as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's CHI White Sox-Cleveland game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Guardians' chance of winning at 63%, with the White Sox at 37%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive White Sox vs. Guardians predictions page.

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White Sox vs. White Sox Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and statistical analysis, we have simulated the result of Wednesday's MLB game between the White Sox and Guardians 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Guardians a 63% chance of defeating the White Sox.

According to our model, the White Sox (+1.5) have a 57% chance of covering the run line, while the 7.5-run over/under has a 51% chance of going over.

Pre-Game Probabilities

Last Updated: 11:27PM, Apr 9

Moneyline

Over / Under

Run Line

White Sox

Win %

37%

63%

+150

-168

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Guardians

White Sox CWS

+150

Win %

37%

63%

See Matchup

Guardians CLE

-168

Sean Burke 1-1, 5.23 ERA

Logan Allen 0-1, 6.75 ERA

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White Sox vs. Guardians Odds [4/9/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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White Sox vs. Guardians Picks and Best Bets

Our model's strongest edge in today's White Sox vs. Guardians matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

White Sox vs. Guardians Game-Day Updates and Essential Details

Wednesday's MLB game between the Guardians and White Sox at Progressive Field is scheduled to begin at 6:10PM ET.

• Who: Chicago White Sox vs. Cleveland Guardians
• Date: Wednesday, April 9, 2025
• Time: 6:10PM ET/3:10PM PT
• Venue: Progressive Field

Dimers.com's comprehensive preview of Wednesday's White Sox vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any CHI White Sox vs. Cleveland picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Guardians, with a 63% win probability, will likely beat the White Sox on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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