White Sox vs. Guardians Prediction: Cleveland Predicted to Win Tuesday's MLB Matchup [4/8/2025]

The Cleveland Guardians will face the Chicago White Sox in MLB action at Progressive Field on Tuesday, commencing at 4:10PM ET.

Ben Lively (0-1, 6.75 ERA) will be on the bump for the Guardians, while the White Sox are going with Shane Smith (0-0, 3.18 ERA).

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Guardians as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's CHI White Sox-Cleveland game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Guardians with a win probability of 63%, compared to 37% for the White Sox."

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive White Sox vs. Guardians predictions page.

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White Sox vs. White Sox Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the outcome of Tuesday's MLB game between the White Sox and Guardians 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Guardians a 63% chance of defeating the White Sox.

According to our model, the White Sox (+1.5) have a 56% chance of covering the run line, while the 7.5-run over/under has a 51% chance of going over.

Pre-Game Probabilities

Last Updated: 8:28PM, Apr 8

Moneyline

Over / Under

Run Line

White Sox

Win %

37%

63%

+170

-186

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Guardians

White Sox CWS

+170

Win %

37%

63%

See Matchup

Guardians CLE

-186

Shane Smith 0-0, 3.18 ERA

Ben Lively 0-1, 6.75 ERA

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White Sox vs. Guardians Odds [4/8/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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White Sox vs. Guardians Picks and Best Bets

Our model's biggest edge in today's White Sox vs. Guardians matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

White Sox vs. Guardians Game-Day Updates and Essential Details

Tuesday's MLB game between the Guardians and White Sox at Progressive Field is scheduled to begin at 4:10PM ET.

• Who: Chicago White Sox vs. Cleveland Guardians
• Date: Tuesday, April 8, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: Progressive Field

Dimers.com's comprehensive preview of Tuesday's White Sox vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any CHI White Sox vs. Cleveland picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Guardians, with a 63% win probability, will likely beat the White Sox on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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