White Sox vs. Guardians Prediction: Cleveland Predicted to Win Thursday's MLB Matchup [4/10/2025]

The Cleveland Guardians will square off with the Chicago White Sox in MLB action at Progressive Field on Thursday, starting at 1:10PM ET.

Gavin Williams (0-0, 4.50 ERA) will get the ball for the Guardians, pitting him against Jonathan Cannon (0-1, 3.12 ERA) for the White Sox.

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Guardians as the most likely winner of today's game.

"Using the latest data, our experts simulated Thursday's CHI White Sox-Cleveland game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast the Guardians with a win probability of 67% and the White Sox with 33%."

For expanded analysis of Thursday's matchup, including best bets and picks, visit our interactive White Sox vs. Guardians predictions page.

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White Sox vs. White Sox Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data analysis, we have simulated the outcome of Thursday's MLB matchup between the White Sox and Guardians 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Guardians a 67% chance of beating the White Sox.

According to our model, the White Sox (+1.5) have a 52% chance of covering the run line, while the over/under total of 7.5 runs has a 51% chance of going over.

Pre-Game Probabilities

Last Updated: 5:27PM, Apr 10

Moneyline

Over / Under

Run Line

White Sox

Win %

32%

68%

+205

-245

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Guardians

White Sox CWS

+205

Win %

32%

68%

See Matchup

Guardians CLE

-245

Jonathan Cannon 0-1, 3.12 ERA

Gavin Williams 0-0, 4.50 ERA

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White Sox vs. Guardians Odds [4/10/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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White Sox vs. Guardians Picks and Best Bets

Our model's biggest edge in today's White Sox vs. Guardians matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

White Sox vs. Guardians Game-Day Updates and Essential Details

Thursday's MLB matchup between the Guardians and White Sox at Progressive Field is scheduled to start at 1:10PM ET.

• Who: Chicago White Sox vs. Cleveland Guardians
• Date: Thursday, April 10, 2025
• Time: 1:10PM ET/10:10AM PT
• Venue: Progressive Field

Dimers.com's comprehensive preview of Thursday's White Sox vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any CHI White Sox vs. Cleveland picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Guardians, with a 67% win probability, will likely beat the White Sox on Thursday.

AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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