White Sox vs. Red Sox Prediction: Boston Predicted to Win Monday's MLB Matchup [4/21/2025]

The Boston Red Sox will square off with the Chicago White Sox in MLB action at Fenway Park on Monday, starting at 11:10AM ET.

Walker Buehler (2-1, 5.23 ERA) will be on the bump for the Red Sox, pitting him against Jonathan Cannon (0-2, 4.42 ERA) for the White Sox.

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Red Sox as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's CHI White Sox-Boston game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Red Sox are likely to win, with a probability of 70%, compared to the White Sox' 30%."

For a closer look at Monday's matchup, including best bets and picks, visit our interactive White Sox vs. Red Sox predictions page.

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White Sox vs. White Sox Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data analysis, we have simulated the outcome of Monday's MLB game between the White Sox and Red Sox 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Red Sox a 70% chance of defeating the White Sox.

According to our model, the Red Sox (-1.5) have a 52% chance of covering the run line, while the over/under total of 9 runs has a 54% chance of staying under.

Pre-Game Probabilities

Last Updated: 3:29PM, Apr 21

Moneyline

Over / Under

Run Line

White Sox

Win %

30%

70%

+245

-278

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Red Sox

White Sox CWS

+245

Win %

30%

70%

See Matchup

Red Sox BOS

-278

Jonathan Cannon 0-2, 4.42 ERA

Walker Buehler 2-1, 5.23 ERA

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White Sox vs. Red Sox Odds [4/21/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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White Sox vs. Red Sox Picks and Best Bets

Our model's biggest edge in today's White Sox vs. Red Sox matchup is on the over/under.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

White Sox vs. Red Sox Game-Day Updates and Essential Details

Monday's MLB game between the Red Sox and White Sox at Fenway Park is scheduled to start at 11:10AM ET.

• Who: Chicago White Sox vs. Boston Red Sox
• Date: Monday, April 21, 2025
• Time: 11:10AM ET/8:10AM PT
• Venue: Fenway Park

Dimers.com's comprehensive preview of Monday's White Sox vs. Red Sox matchup includes our prediction, picks and the latest betting odds.

Before making any CHI White Sox vs. Boston picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Red Sox, with a 70% win probability, will likely beat the White Sox on Monday.

AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Red Sox insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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