Cubs vs. Padres Prediction: San Diego Predicted to Win Wednesday's MLB Matchup [4/16/2025]

The San Diego Padres will square off with the Chicago Cubs in MLB action at PETCO Park on Wednesday, commencing at 4:10PM ET.

Nick Pivetta (2-1, 1.59 ERA) will be on the bump for the Padres, up against Matthew Boyd (1-1, 1.59 ERA) for the Cubs.

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's CHI Cubs-San Diego game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Padres' chance of winning at 53%, with the Cubs at 47%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Cubs vs. Padres predictions page.

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Cubs vs. Cubs Prediction: Who Will Win?

Using innovative machine learning and data, we have simulated the outcome of Wednesday's MLB game between the Cubs and Padres 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Padres a 53% chance of beating the Cubs.

According to our model, the over/under total of 7.5 runs has a 51% chance of staying under.

Cubs vs. Padres Odds [4/16/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Padres Picks and Best Bets

Our model's strongest edge in today's Cubs vs. Padres matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Cubs vs. Padres Game-Day Updates and Essential Details

Wednesday's MLB action between the Padres and Cubs at PETCO Park is scheduled to begin at 4:10PM ET.

• Who: Chicago Cubs vs. San Diego Padres
• Date: Wednesday, April 16, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: PETCO Park

Dimers.com's comprehensive preview of Wednesday's Cubs vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any CHI Cubs vs. San Diego picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Padres, with a 53% win probability, will likely beat the Cubs on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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