Chargers vs. Broncos Predictions and Odds - Nov 28, 2021

The Denver Broncos face the Los Angeles Chargers in NFL Week 12 action at Empower Field at Mile High on Sunday, commencing at 4:05 PM EST.

Dimers' top betting picks for Chargers vs. Broncos, as well as game predictions and best odds, are featured in this article.

Who will win Chargers vs. Broncos?

Based on state-of-the-art machine learning and data, Dimers.com has simulated Sunday's Chargers-Broncos game 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, gives the Chargers a 62% chance of getting the W against the Broncos.

MORE: Chargers vs. Broncos Simulated 10,000 Times

Chargers vs. Broncos Point Spread, Moneyline and Over/Under

The Broncos are +2.5 underdogs at home to the Chargers, with +100 at DraftKings Sportsbook the best odds available.

For the favored Chargers (-2.5) to cover the spread, DraftKings Sportsbook also has the best odds on the market at -120.

BetMGM has the best moneyline odds for the Broncos at +135, which means you can bet $100 to profit $135, earning a total payout of $235, if they win.

Elsewhere, DraftKings Sportsbook has the best moneyline odds for the Chargers at -145, where you can risk $145 to win $100, for a total payout of $245, if they come out on top.

The Over/Under is set at 47 with DraftKings Sportsbook, which has the best odds for the Over at -105, while Caesars Sportsbook has the best odds for the Under at -110.

As always, make sure you check the sportsbooks you can bet with in your state for the best NFL odds and lines.

According to DimersBOT, the Chargers (-2.5) are a 56% chance of covering the spread, while the 47-point Over/Under is a 52% chance of going Over.

MORE: Predictions for Every NFL Game

Best Bets for Chargers vs. Broncos

• Spread: Chargers -2.5 at -120 with DraftKings Sportsbook (56% probability)
• Moneyline: Chargers Win at -145 with DraftKings Sportsbook (62% probability)
• Over/Under: Over 47 at -105 with DraftKings Sportsbook (52% probability)

Chargers vs. Broncos Score Prediction

Dimers.com's predicted final score for LA Chargers vs. Denver at Empower Field at Mile High this Sunday has the Chargers winning 25-22.

Use our interactive widget below to explore the latest Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup to reveal more.

Dimers has full betting coverage of this week's Chargers-Broncos matchup, including pre-game predictions, computer picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so check this page for the latest betting insights before Chargers vs. Broncos on Sunday November 28, 2021.

Chargers vs. Broncos 2021 Game Info

When do the Broncos play the Chargers?

• Date: Sunday November 28, 2021
• Time: 4:05 PM EST / 1:05 PM PST
• Venue: Empower Field at Mile High

Want to join an online sportsbook and start betting on the NFL? We've listed the best available welcome offers for each and every legal betting state.

Want more NFL previews like this?

To get more NFL betting previews like this one for Chargers vs. Broncos, all you've gotta do is visit Dimers' NFL Betting News section. It's that easy – they're all there!

We use the power of predictive analytics to find edges in the markets so we can produce the most comprehensive NFL betting previews available. We do this by comparing our own probabilities against the sportsbooks' odds (aka Vegas odds) the minute they go live.

So, get ahead of the game and beat the 'books today – it's only a click away.