College Football Best Bets: Three Favorite Picks for Week 13 of the 2022 Season

We already dished out some plays for a loaded Friday college slate, but now we're back with three more for a Saturday that is packed with rivalry games. This slate features some really exciting matchups and we previewed some of the biggest ones earlier in the week. But the ones below are the moneymakers, as we're trying to find the sharpest picks of the weekend. 

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RELATED: College Football Bet Hub 

Week 13 College Football Best Bets 

Louisville Cardinals vs. Kentucky Wildcats - 3:00PM ET

Louisville has won and covered in five of its last six games and now faces a Kentucky team that has lost three of its last four. Of course, betting an ACC team against an SEC team is always a scary proposition, but the Cardinals are just playing some great football right now. Meanwhile, the Wildcats are really struggling to put up points. 

Kentucky has scored 21 or fewer points in six of its last seven games, which isn't good when you factor in that Louisville has put up at least 31 points in six of its last nine. It's just unclear how the Wildcats will handle shutting down this Cardinals offense, and Louisville's defense is going to be feeling great about slowing down Kentucky. 

Will Levis might be an NFL prospect, but it just hasn't resulted in any sort of real production for the Wildcats. It's just an easy call to roll with the road team here. 

BET: Louisville +3 at -110 at DraftKings Sportsbook

🏈 Louisville vs. Kentucky Predictions
📈 Betting preview: Louisville vs. Kentucky

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Oregon Ducks vs. Oregon State Beavers - 3:30PM ET

Oregon State is a ridiculous 11-0 against the spread in home games over the last two seasons and we don't expect the Beavers to mess with that perfect record here. Not only is this one of the best rivalries in the Pac-12, but Oregon State also has the added bonus of having an opportunity to spoil its rival's season. 

The Ducks are also a bit compromised offensively coming into this game. Bo Nix, who looked like a legitimate Heisman contender for most of the year, has been banged up for Oregon. His movement didn't look like it was there last week and that's a pretty big deal in this spot. Oregon needs Nix to be able to use his legs if it is going to want to win on the road, but we just don't anticipate him being able to do so. The Beavers also happen to have a great rushing defense. That could make it hard for the Ducks to establish any type of rhythm offensively. 

Oregon State should also be able to do a bit more in the passing game than we saw earlier in the year. Ben Gulbranson has been a spark for the Beavers under center and we think he can have a good game against the Ducks. All in all, we're rolling with Oregon State to cover and think it's worth a sprinkle on the moneyline. 

BET: Oregon State +3.5 at -110 at DraftKings Sportsbook

🏈 Oregon vs. Oregon State Predictions
📈 Betting preview: Oregon vs. Oregon State

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Minnesota Golden Gophers vs. Wisconsin Badgers - 3:30PM ET

If Jim Leonhard wants to remove all doubt and make a definitive claim for the Wisconsin head coaching position then he'll need his Badgers to secure Paul Bunyan's Axe. Wisconsin is fresh off an impressive comeback win over Nebraska last week, but the team has an opportunity to get to seven wins on Saturday and needs to take advantage. A six-win season with the Badgers would be looked at as a massive failure, and the same can be said for losing to a hated rival in Madison. 

One thing we like heading into this game is that Wisconsin has held back-to-back opponents to under 100 yards rushing. The Badgers would be in great position to win this game if they can similarly shut down Mohamed Ibrahim and the Golden Gophers rushing attack. 

Wisconsin could also struggle to put up some points in this game, but we have faith in the Badgers getting the job done at home in what is a game the players will really want to win. Wisconsin's players have been very vocal about wanting Leonhard to stay and they have a chance to help him do so on Saturday. 

BET: Wisconsin -3 at -110 at DraftKings Sportsbook

🏈 Minnesota vs. Wisconsin Predictions
📈 Betting preview: Minnesota vs. Wisconsin