Cardinals vs. Royals Prediction and Odds - May 4, 2022

The Kansas City Royals square off with the St Louis Cardinals in MLB action at Kauffman Stadium on Wednesday, beginning at 1:10PM ET.

Kris Bubic (0-2, 10.50 ERA) will start for the Royals, up against Adam Wainwright (2-3, 4.00 ERA) for the Cardinals.

Dimers' best betting picks for Cardinals vs. Royals, as well as game predictions and best odds, are featured in this article.

Today's St Louis vs. Kansas City betting preview is sponsored by PointsBet, which has a great 5x $100 Risk-Free Bets offer for new users.

Who will win Cardinals vs. Royals?

Using state-of-the-art machine learning and data, Dimers.com has simulated Wednesday's Cardinals-Royals MLB game 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, currently gives the Cardinals a 56% chance of winning against the Royals.

More: Cardinals vs. Royals Simulated 10,000 Times

Cardinals vs. Royals Odds

• Run Line: Royals +1.5 (-140), Cardinals -1.5 (+126)
• Moneyline: Royals +125, Cardinals -142
• Total: Over/Under 7.5 (-115/+100)

Run Line, Moneyline and Over/Under

The Royals are +1.5 underdogs versus the Cardinals, with -140 at PointsBet the best odds currently available.

For the favored Cardinals (-1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at +126.

BetMGM currently has the best moneyline odds for the Royals at +125. That means you can throw down $100 to profit $125, earning a total payout of $225, if they win.

On the other hand, FanDuel Sportsbook currently has the best moneyline odds for the Cardinals at -142, where you can risk $142 to win $100, for a total payout of $242, if they come out on top.

The Over/Under sits at 7.5 with DraftKings Sportsbook, which currently has the best odds for the Over at -115, while BetMGM currently has the best odds for the Under at +100.

As always, make sure you check all the legal sportbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Royals (+1.5) are a 58% chance of covering the run line, while the 7.5-run Over/Under is a 56% chance of going Over.

More: Best Bets for Every MLB Matchup

Best Bets for Cardinals vs. Royals

• Run Line: Royals +1.5 @ -140 via PointsBet (58% probability)
• Moneyline: Royals @ +125 via BetMGM
• Total: Over 7.5 @ -115 via DraftKings Sportsbook (56% probability)

Dimers' best bets are based on world-class simulations and betting intelligence to serve you the best possible plays every time.

While the Cardinals are more likely to win the game, according to DimersBOT, taking the Royals moneyline is the best option due to the edge found when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges published on Dimers is crucial to achieving long-term profitability as a bettor.

Cardinals vs. Royals Probabilities

Use our widget below to view up-to-date Moneyline, Over/Under and Run Line probabilities and odds for St Louis vs. Kansas City, and click or tap on See Matchup for more.

Dimers has full coverage of Wednesday's Cardinals-Royals matchup, including pregame predictions, best betting picks, and live win probabilities.

Don't forget, DimersBOT updates frequently, so refresh this article for the latest betting insights ahead of Cardinals vs. Royals on Wednesday May 4, 2022.

Best Betting Promo for Cardinals vs. Royals

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Cardinals vs. Royals 2022 Game Info

When do the Royals play the Cardinals?

• Date: Wednesday May 4, 2022
• Time: 1:10PM ET / 10:10AM PT
• Venue: Kauffman Stadium

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What other MLB games are on today?

Now you've got the 411 on Cardinals vs. Royals, get the latest betting analysis for all upcoming MLB games in our MLB Bet Hub, where you can find probabilities and odds, as well as our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

While you're here, Dimers' Baseball Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities paired with the best odds available.