Cardinals vs. Padres Prediction for MLB Friday [9/22/2023]

The San Diego Padres will square off with the St. Louis Cardinals in MLB action at PETCO Park on Friday, starting at 9:40PM ET.

Matt Waldron (1-3, 5.16 ERA) will be on the bump for the Padres, up against Dakota Hudson (6-2, 5.12 ERA) for the Cardinals.

Dimers' top betting picks for Cardinals vs. Padres, plus game predictions and best odds, are detailed in this article.

Who Will Win: Cardinals vs. Padres

Using state-of-the-art computer power and data, Dimers.com has simulated Friday's Cardinals-Padres MLB matchup 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, currently gives the Padres a 60% chance of defeating the Cardinals.

More: Betting Predictions for Cardinals vs. Padres

Cardinals vs. Padres Odds [9/22]

• Run Line: Padres -1.5 (+120), Cardinals +1.5 (-134)
• Moneyline: Padres -175, Cardinals +154
• Total: Over/Under 9 (-105/-110)

The Padres are -1.5 favorites versus the Cardinals, with +120 at PointsBet the best odds currently available.

For the underdog Cardinals (+1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on the market at -134.

BetMGM currently has the best moneyline odds for the Padres at -175, which means you can risk $175 to win $100, for a total payout of $275, if they get the W.

On the other hand, FanDuel Sportsbook currently has the best moneyline odds for the Cardinals at +154, where you can put down $100 to profit $154, earning a total payout of $254, if they win.

The Over/Under sits at 9 with BetMGM, which currently has the best odds for the Over at -105, while PointsBet currently has the best odds for the Under at -110.

As always, check out the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Cardinals (+1.5) have a 58% chance of covering the run line, while the 9-run Over/Under has a 53% chance of going Over.

More: Live Scores for All Major Sports

Best Bets: Cardinals vs. Padres

• Run Line: Cardinals +1.5 @ -134 via FanDuel Sportsbook (58% probability)
• Moneyline: Cardinals @ +154 via FanDuel Sportsbook (0.7% edge)
• Total: Over 9 @ -105 via BetMGM (53% probability)

Dimers' best bets are based on complex simulations and gambling intelligence to serve you the best possible plays every time.

While the Padres are more likely to win the game, according to DimersBOT, taking the Cardinals moneyline is the best option because of the edge found when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges seen on Dimers is one of the keys to achieving long-term profitability.

Cardinals vs. Padres Prediction

Dimers.com predicts that the Padres are more likely to beat the Cardinals in the MLB game on Friday.

This prediction is backed by extensive data-driven analysis, with the Padres boasting a 60% probability of winning after conducting 10,000 simulations of the game.

Click or tap on See Matchup to find out more.

Dimers has full betting coverage of Friday's Cardinals-Padres game, including pregame predictions, computer picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so refresh this page for the latest betting analysis before Cardinals vs. Padres on Friday September 22, 2023.

Cardinals vs. Padres 2023

Friday's MLB matchup between the Padres and Cardinals at PETCO Park is scheduled to begin at 9:40PM ET.

• Who: St. Louis Cardinals vs. San Diego Padres
• Date: Friday September 22, 2023
• Time: 9:40PM ET / 6:40PM PT
• Venue: PETCO Park

Looking to join an online sportsbook and start betting on MLB now? We've reviewed the best available sign-up offers in each and every legal betting state.

Calling Our Shot ⚾️ Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Make Smarter Sports Betting Decisions Today

Dimers' predictions are made after 10,000 simulations per game, using reliable and up-to-date data sources and analytical methods.

While these Cardinals vs. Padres predictions can help you make informed decisions, it's vital that you gamble responsibly and manage your bankroll effectively.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Want More MLB Predictions Like This?

So, you liked our Cardinals vs. Padres betting predictions? Awesome. Did you know our MLB Betting News section has a comprehensive betting preview for every MLB game as soon as the sportsbooks release their odds?

That's right, our predictive analytics model then compares those odds against its own probabilities to find edges in the markets. This allows us to produce the most reliable MLB betting previews and get the jump on the public and the sportsbooks.

In addition to our leading MLB predictions, we also feature the best MLB prop bets today, projecting home runs, RBIs, and more against the best odds available every day of the MLB season.

Lastly, Dimers' MLB Futures page is our in-house approach to revealing who will win the World Series, with our data-driven probabilities paired with the best odds available.