Cardinals vs. Guardians Prediction for MLB Friday [5/26/2023]

The Cleveland Guardians take on the St. Louis Cardinals in MLB action at Progressive Field on Friday, beginning at 7:10PM ET.

Shane Bieber (3-3, 3.08 ERA) will be on the bump for the Guardians, up against Matthew Liberatore (1-0, 3.00 ERA) for the Cardinals.

Dimers' best betting picks for Cardinals vs. Guardians, plus game predictions and betting odds, are detailed below.

Who Will Win: Cardinals vs. Guardians

Using state-of-the-art machine learning and data, Dimers.com has simulated Friday's Cardinals-Guardians MLB matchup 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, currently can't split the two teams, giving both the Cardinals and Guardians a 50% chance of winning the game.

More: Cardinals vs. Guardians Simulated 10,000 Times

Cardinals vs. Guardians Current Odds

• Run Line: Guardians +1.5 (-194), Cardinals -1.5 (+165)
• Moneyline: Guardians -110, Cardinals +100
• Total: Over/Under 7.5 (-115/+100)

Run Line, Moneyline and Over/Under

The Guardians are +1.5 underdogs versus the Cardinals, with -194 at FanDuel Sportsbook the best odds currently available.

For the favored Cardinals (-1.5) to cover the run line, BetMGM has the best odds currently on the market at +165.

PointsBet currently has the best moneyline odds for the Guardians at -110. That means you can risk $110 to win $100, for a total payout of $210, if they get the W.

Elsewhere, DraftKings Sportsbook currently has the best moneyline odds for the Cardinals at +100, where you can risk $100 to win $100, for a total payout of $200, if they come out on top.

The Over/Under for total runs scored sits at 7.5 with BetMGM, which currently has the best odds for the Over at -115, while DraftKings Sportsbook currently has the best odds for the Under at +100.

As always, make sure you check all the legal sportbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) have a 63% chance of covering the run line, while the Over/Under total of 7.5 runs has a 55% chance of going Over.

More: Free Prop Picks

Best Bets for Cardinals vs. Guardians

• Run Line: Cardinals -1.5 @ +165 via BetMGM
• Moneyline: Cardinals @ +100 via DraftKings Sportsbook (50% probability)
• Total: Over 7.5 @ -115 via BetMGM (55% probability)

Our best bets are based on complex modeling and betting intelligence to help you make smarter decisions with your state's legal sportsbooks.

Although the Guardians are more likely to cover the run line, our best bet of Cardinals -1.5 is based on the expectation of that happening, according to DimersBOT, and the top odds available.

Cardinals vs. Guardians Prediction

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Dimers has full betting coverage of Friday's Cardinals-Guardians matchup, including pregame predictions, computer picks, and live win probabilities.

Don't forget, DimersBOT updates frequently, so check this article for the latest betting insights before Cardinals vs. Guardians on Friday May 26, 2023.

Cardinals vs. Guardians 2023

Friday's action between the Guardians and Cardinals at Progressive Field is scheduled to commence at 7:10PM ET.

• Who: St. Louis Cardinals vs. Cleveland Guardians
• Date: Friday May 26, 2023
• Time: 7:10PM ET / 4:10PM PT
• Venue: Progressive Field

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Calling Our Shot ⚾️ Free Picks

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Make Informed Sports Betting Decisions with Dimers

Dimers' picks and predictions are based on 10,000 simulations per game, using reliable and up-to-date data sources and analytical methods.

While these Cardinals vs. Guardians picks can help you make informed decisions, it's important that you only bet what you can afford to lose and manage your finances effectively.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

What Other MLB Games Are on Today?

The Cardinals and Guardians aren't the only two MLB teams you can bet on today. DimersBOT never stops and we've got picks and best bets for every single MLB game via our MLB Predictions section.

Not only do we provide with you first-class predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Hell yeah it does!

In addition to MLB picks and predictions, we also provide the best MLB prop bets for today, projecting home runs, RBIs, and more against the best odds available every single day of the MLB season.

While you're here, Dimers' Baseball Futures page is our in-house approach to revealing who will win the World Series, with our data-led probabilities compared to the best odds available.