Buffalo Bills vs. New England Patriots Early Predictions for NFL Week 18: Odds, Picks and Preview [2025]

The New England Patriots and Buffalo Bills will lock horns in Week 18 of the NFL season at Gillette Stadium on Sunday, January 5, 2025, with kickoff set for 1:00PM ET.

Early simulation results from Dimers' advanced NFL model favor the Bills as the most likely winner of this showdown.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Bills vs. Patriots predictions page.

Bills vs. Patriots Week 18 Details

The NFL Week 18 game between the Patriots and Bills at Gillette Stadium is scheduled for January 5, 2025.

• Who: Buffalo Bills vs. New England Patriots
• Date: Sunday, January 5, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Gillette Stadium

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Bills vs. Patriots Latest Odds

We've researched the best betting odds across America for this Week 18 game, detailed below:

• Spread: Bills -2 (-112), Patriots +2 (-105)
• Moneyline: Bills -125, Patriots +115
• Total: Over/Under 38.5 (-105/-115)

Buffalo vs. New England Early Predictions

Leveraging powerful machine learning and analysis, we have simulated the Bills vs. Patriots game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight Up Win Probabilities: Bills 59%, Patriots 41%
• Predicted Final Score: Bills 20-18 Patriots
• Spread: Bills (-2) 50%, Patriots (+2) 50%
• Total Points (38.5): Over 52%, Under 48%

As of January 2, 2025, these Bills-Patriots predictions reflect the latest data and insights available.

Anytime Touchdown Scorer Predictions

Here are our initial touchdown probabilities for the Bills-Patriots matchup:

Buffalo Bills

• Ray Davis: 26.9% probability
• James Cook: 24.6% probability
• Keon Coleman: 23.9% probability

New England Patriots

• Antonio Gibson: 26.0% probability
• Rhamondre Stevenson: 24.1% probability
• Kayshon Boutte: 23.4% probability

Bills vs Patriots Player Props

Ray Davis is projected to lead rushing for the Bills, while Rhamondre Stevenson is expected to pace the Patriots on the ground.

In the receiving game, our projections favor Buffalo's Keon Coleman and New England's DeMario Douglas as the likely leaders for each team.

Conclusion

We predict the Bills, with a 59% win probability, will likely beat the Patriots in Week 18 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Bills vs. Patriots matchup, with human oversight maintaining high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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