Buffalo Bills vs. Los Angeles Chargers Prediction, Odds, NFL Picks - Week 16 [2023]

The Los Angeles Chargers and Buffalo Bills will meet in Week 16 of the NFL season at SoFi Stadium on Saturday, with kickoff at 8:00PM ET.

Dimers.com's comprehensive betting preview for Saturday's Bills vs. Chargers matchup includes the latest betting odds, as well as our predictions and picks for the game.

Bills vs. Chargers Prediction: Who Will Win, Cover the Spread

We have used advanced machine learning and data analysis to simulate the outcome of Saturday's NFL game between the Bills and Chargers 10,000 times, in line with our coverage of NFL picks.

Our famous predictive analytics model gives the Bills an 89% chance of defeating the Chargers in Week 16 of the NFL season, and our predicted final score has the Bills winning 28-15.

According to our model, the Bills (-12.5) have a 51% chance of covering the spread, while the 44.5-point Over/Under has a 56% chance of going under.

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Bills vs. Chargers Odds

We have researched the best betting odds in America for this game, which are listed here:

Bet Type	Bills	Chargers
Spread	-12.5 (-105)	+12.5 (-110)
Moneyline	-750	+550
Total	o44.5 (-105)	u44.5 (-110)

• The Chargers are +12.5 underdogs against the Bills, with -110 at BetMGM Sportsbook the best odds currently available.
• For the favored Bills (-12.5) to cover the spread, FanDuel Sportsbook has the best odds currently on offer at -105.
• BetMGM currently has the best moneyline odds for the Chargers at +550. That means you can throw down $100 to profit $550, earning a total payout of $650, if they win.
• On the other hand, FanDuel currently has the best moneyline odds for the Bills at -750, where you can risk $750 to win $100 for a total payout of $850 if they come out on top.
• The Over/Under for total points scored sits at 44.5 with DraftKings Sportsbook, which currently has the best odds for the Over at -105, while FanDuel currently has the best odds for the Under at -110.

All odds are correct at the time of publication and are subject to change.

As always, make sure you check the sportsbooks you can bet with in your state for the best NFL odds and lines.

Bills vs. Chargers Picks

By comparing our probabilities to the odds listed above, we have determined the best betting picks to make on this game:

Bet Type	Our Pick	Best Odds
Spread	Bills -12.5	-105
Moneyline	Bills	-750
Total	Under 44.5	-110

Dimers' NFL best bets are based on world-class simulations and wagering intelligence to bring you the best possible plays every week of the season.

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Bills vs. Chargers TD Scorers

Who will score the first touchdown in Bills vs. Chargers?

According to our model, Buffalo's James Cook is most likely to score the first TD in Bills vs. Chargers.

Our projections give Cook a 12.1% chance of scoring the first TD at SoFi Stadium, while the Bills RB is a 47.1% chance of scoring an anytime touchdown.

First Touchdown Scorer Predictions

Buffalo Bills

Player	First TD Probability
James Cook	12.1%
Josh Allen	11.3%
Stefon Diggs	9.8%
Gabe Davis	7.4%
Dalton Kincaid	6.0%

Los Angeles Chargers

Player	First TD Probability
Austin Ekeler	7.2%
Joshua Palmer	4.6%
Gerald Everett	4.4%
Quentin Johnston	3.3%
Isaiah Spiller	3.1%

Anytime Touchdown Scorer Predictions

Buffalo Bills

Player	Anytime TD Probability
James Cook	47.1%
Josh Allen	44.9%
Stefon Diggs	40.0%
Gabe Davis	30.7%
Dalton Kincaid	26.2%

Los Angeles Chargers

Player	Anytime TD Probability
Austin Ekeler	32.7%
Joshua Palmer	22.4%
Gerald Everett	20.4%
Quentin Johnston	16.0%
Isaiah Spiller	14.5%

Bills vs Chargers Player Props

Here, you will find detailed projections for all of the key offensive players from the Bills and Chargers, including passing, rushing and receiving yards.

Bills vs. Chargers Quarterbacks

Of the starting quarterbacks, the Bills' Josh Allen is projected for 253 passing yards. The Chargers' Easton Stick is expected to throw for just 186 yards.

Player	Proj. Pass Yards
Josh Allen (BUF)	253 yds
Easton Stick (LAC)	186 yds

Bills Rushing

Player	Proj. Rush Yards
James Cook	60 yds
Latavius Murray	28 yds
Josh Allen	19 yds

Chargers Rushing

Player	Proj. Rush Yards
Austin Ekeler	44 yds
Isaiah Spiller	25 yds
Easton Stick	18 yds

Bills Receiving

Player	Proj. Rec. Yards
Stefon Diggs	80 yds
Dalton Kincaid	38 yds
Gabe Davis	32 yds
James Cook	22 yds
Khalil Shakir	21 yds

Chargers Receiving

Player	Proj. Rec. Yards
Gerald Everett	41 yds
Joshua Palmer	40 yds
Quentin Johnston	34 yds
Austin Ekeler	26 yds
Jalen Guyton	23 yds

Remember, our model updates often, so keep an eye on this article for any changes to our betting insights before the Bills vs. Chargers on Saturday December 23, 2023.

Bills vs. Chargers Game Information

The NFL Week 16 matchup between the Chargers and Bills at SoFi Stadium is scheduled to begin at 8:00PM ET.

• Who: Buffalo Bills vs. Los Angeles Chargers
• Date: Saturday December 23, 2023
• Time: 8:00PM ET / 5:00PM PT
• Venue: SoFi Stadium

Our full coverage of Bills vs. Chargers includes pregame predictions, betting picks, and live updates.

How to Bet on Bills vs. Chargers

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Conclusion

This preview article has been partially generated using automated processes and AI technology. Our goal is to provide timely and accurate updates on Bills vs. Chargers Week 14 clash, and automation assists in data collection, analysis, and formatting. Human editing and quality control are performed to ensure the content meets our editorial standards.

Dimers' predictions are made thanks to 10,000 simulations per game, using reliable and up-to-date data sources and analytical methods. While these Bills vs. Chargers picks can help you make informed decisions, it's important that you gamble responsibly and manage your finances effectively.

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