Bills vs. Colts Prediction: Buffalo Predicted to Win in NFL Week 10 [2024]

The Indianapolis Colts will face the favored Buffalo Bills in NFL Week 10 action at Lucas Oil Stadium on Sunday, starting at 1:00PM ET.

Based on updated simulations, Dimers' proven NFL model (see Dimers Pro for full access) predicts the Bills as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Bills-Colts game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Bills with a win probability of 65%, while the Colts have 35%."

This updated Bills vs. Colts betting preview is a follow-up on our early Bills vs. Colts prediction that was published at the start of the week.

For more detail on today’s game, including the predicted score, best bets and player prop picks, check out our interactive Bills vs. Colts predictions page.

Bills vs. Colts Game-Day Updates and Essential Details

The NFL Week 10 matchup between the Colts and Bills at Lucas Oil Stadium is scheduled to begin at 1:00PM ET.

• Who: Buffalo Bills vs. Indianapolis Colts
• Date: Sunday, November 10, 2024
• Time: 1:00PM ET/10:00AM PT
• Venue: Lucas Oil Stadium
• Tickets: Get tickets for the game on Ticketmaster
• Merchandise: Buy Colts and Bills gear at Fanatics

Dimers.com's comprehensive preview of Sunday's Bills vs. Colts matchup includes our prediction, picks and the latest betting odds.

Before making any Buffalo vs. Indianapolis picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

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Bills vs. Colts Predictions

Using trusted machine learning and data, we have simulated the outcome of Sunday's NFL game between the Bills and Colts 10,000 times as part of our NFL predictions coverage.

Our famous predictive model currently gives the Bills a 65% chance of beating the Colts in Week 10 of the NFL season. Our predicted final score has the Bills winning 25-21.

According to our model, the Colts (+4.5) have a 54% chance of covering the spread, while the 46.5-point over/under has an equal 50-50 chance of hitting.

In addition to our Bills vs. Colts predictions, we've also prepared the following for today’s action:

• NFL Best Bets for Week 10
• NFL Player Props for Week 10
• Anytime TD Scorer Predictions for Week 10

Bills vs. Colts Odds

We have researched the best betting odds in America for this game, which are listed here:

Bet Type	Bills	Colts
Spread	-4.5 (-105)	+4.5 (-105)
Moneyline	-225	+190
Total	o46.5 (-112)	u46.5 (-105)

All odds are correct at the time of publication and are subject to change.

Bills vs. Colts Picks

Our model's strongest edge in today's Bills vs. Colts matchup is on the total.

Our expert predictions, matched against the current odds, reveal the best NFL picks for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Bills vs. Colts TD Scorers

Who will score an anytime touchdown in Bills vs. Colts?

According to our model, Indianapolis' Jonathan Taylor is most likely to score the first touchdown in Bills vs. Colts.

Our projections give Taylor a 15.0% chance of getting in for six first at Lucas Oil Stadium, while the Colts RB is a 58.4% chance of reaching the end zone at any point during the game.

First Touchdown Scorer Predictions

Buffalo Bills

Player	First TD Probability
Josh Allen	12.5%
James Cook	10.1%
Khalil Shakir	7.8%

Indianapolis Colts

Player	First TD Probability
Jonathan Taylor	15.0%
Josh Downs	7.0%
Alec Pierce	5.0%

Anytime Touchdown Scorer Predictions

Buffalo Bills

Player	Anytime TD Probability
Josh Allen	50.3%
James Cook	44.7%
Khalil Shakir	33.5%

Indianapolis Colts

Player	Anytime TD Probability
Jonathan Taylor	58.4%
Josh Downs	33.2%
Joe Flacco	24.2%

For a complete analysis of the most likely first and anytime TD scorers this week, see our NFL Week 10 touchdown scorer predictions

Bills vs Colts Player Props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Bills and Colts. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Bills-Colts page now to access every player prop projection.

Bills vs. Colts Quarterbacks

Of the starting quarterbacks, the Bills' Josh Allen is projected to throw for more yards than the Colts' Joe Flacco.

Bills Rushing

James Cook, Josh Allen and Ray Davis are projected to be the leading rushers for the Bills.

Player	Position
James Cook	RB
Josh Allen	QB
Ray Davis	RB

Colts Rushing

Jonathan Taylor, Trey Sermon and Joe Flacco are expected to lead the Colts in rushing yards.

Player	Position
Jonathan Taylor	RB
Trey Sermon	RB
Joe Flacco	QB

Bills Receiving

Khalil Shakir, Dalton Kincaid, Mack Hollins, James Cook and Ty Johnson are projected to top the receiving yards for the Bills.

Player	Position
Khalil Shakir	WR
Dalton Kincaid	TE
Mack Hollins	WR
James Cook	RB
Ty Johnson	RB

Colts Receiving

Josh Downs, Alec Pierce, Adonai Mitchell, Jonathan Taylor and Ashton Dulin are projected to lead the Colts in receiving yards.

Player	Position
Josh Downs	WR
Alec Pierce	WR
Adonai Mitchell	WR
Jonathan Taylor	RB
Ashton Dulin	WR

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Conclusion

We predict the Bills, with a 65% win probability, will likely beat the Colts in Week 10 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Bills vs. Colts insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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