Buccaneers vs. Colts Predictions and Odds - Nov 28, 2021

The Indianapolis Colts face the Tampa Bay Buccaneers in NFL Week 12 action at Lucas Oil Stadium on Sunday, beginning at 1:00 PM EST.

Dimers' top betting picks for Buccaneers vs. Colts, plus our score prediction and best odds, are featured in this article.

Who will win Buccaneers vs. Colts?

Based on advanced machine learning and data, Dimers.com has simulated Sunday's Buccaneers-Colts matchup 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, gives the Buccaneers a 61% chance of beating the Colts.

MORE: Buccaneers vs. Colts Simulated 10,000 Times

Buccaneers vs. Colts Point Spread, Moneyline and Over/Under

The Colts are +2.5 underdogs against the Buccaneers, with -105 at PointsBet the best odds available.

For the favored Buccaneers (-2.5) to cover the spread, PointsBet also has the best odds on offer at -115.

FanDuel Sportsbook has the best moneyline odds for the Colts at +132. That means you can bet $100 to profit $132, earning a total payout of $232, if they win.

Meanwhile, DraftKings Sportsbook has the best moneyline odds for the Buccaneers at -140, where you can risk $140 to win $100, for a total payout of $240, if they come out on top.

The Over/Under sits at 52.5 with FanDuel Sportsbook, which has the best odds for the Over at -115, as well as the best odds for the Under at -105.

As always, check out all the legal sportbooks available in your state for the best NFL odds and lines.

According to DimersBOT, the Buccaneers (-2.5) are a 56% chance of covering the spread, while the 52.5-point Over/Under is a 51% chance of going Under.

MORE: Predictions for Every NFL Week 12 Matchup

Best Bets for Buccaneers vs. Colts

• Spread: Buccaneers -2.5 at -115 with PointsBet (56% probability)
• Moneyline: Buccaneers Win at -140 with DraftKings Sportsbook (61% probability)
• Over/Under: Under 52.5 at -105 with FanDuel Sportsbook (51% probability)

Buccaneers vs. Colts Score Prediction

Dimers.com's predicted final score for Tampa Bay vs. Indianapolis at Lucas Oil Stadium on Sunday has the Buccaneers winning 27-24.

Use our dynamic widget below to explore the latest Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup for more.

Dimers has full coverage of this week's Buccaneers-Colts matchup, including pre-game predictions, free picks, and live updates.

Remember, DimersBOT updates frequently, so check this article for the latest betting insights before Buccaneers vs. Colts on Sunday November 28, 2021.

Buccaneers vs. Colts 2021 Game Info

When do the Colts play the Buccaneers?

• Date: Sunday November 28, 2021
• Time: 1:00 PM EST / 10:00 AM PST
• Venue: Lucas Oil Stadium

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