Red Sox vs. Guardians Prediction: Boston Predicted to Win Friday's MLB Matchup [4/25/2025]

The Cleveland Guardians and Boston redsox will lock horns in MLB action at Progressive Field on Friday, starting at 7:10PM ET.

Ben Lively (1-2, 3.86 ERA) will get the ball for the Guardians, while the Red Sox have opted for Tanner Houck (0-2, 7.66 ERA).

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Red Sox as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Boston-Cleveland game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Red Sox' chance of winning is 51%, while the Guardians' is 49%."

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Red Sox vs. Guardians predictions page.

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Guardians vs. Red Sox Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Friday's MLB matchup between the Red Sox and Guardians 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Red Sox a 51% chance of beating the Guardians.

According to our model, the Guardians (+1.5) have a 62% chance of covering the run line, while the over/under total of 9 runs has a 52% chance of staying under.

Pre-Game Probabilities

Last Updated: 9:28PM, Apr 25

Moneyline

Over / Under

Run Line

Red Sox

Win %

51%

49%

-108

-105

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Guardians

Red Sox BOS

-108

Win %

51%

49%

See Matchup

Guardians CLE

-105

Tanner Houck 0-2, 7.66 ERA

Ben Lively 1-2, 3.86 ERA

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Red Sox vs. Guardians Odds [4/25/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Red Sox vs. Guardians Picks and Best Bets

Our model's biggest edge in today's Red Sox vs. Guardians matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Red Sox vs. Guardians Game-Day Updates and Essential Details

Friday's MLB matchup between the Guardians and Red Sox at Progressive Field is scheduled to begin at 7:10PM ET.

• Who: Boston Red Sox vs. Cleveland Guardians
• Date: Friday, April 25, 2025
• Time: 7:10PM ET/4:10PM PT
• Venue: Progressive Field

Dimers.com's comprehensive preview of Friday's Red Sox vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Boston vs. Cleveland picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Red Sox, with a 51% win probability, will likely beat the Guardians on Friday.

AI and automation have enhanced this article to quickly deliver accurate Red Sox vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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