Bills vs. Rams Week 1 Prediction and Odds - Sep 8, 2022

The Los Angeles Rams take on the Buffalo Bills in NFL Week 1 action at SoFi Stadium on Thursday, beginning at 8:20PM ET.

Dimers' top betting picks for Bills vs. Rams, plus game predictions, betting odds and touchdown scorer probabilities, are featured in this article.

Today's Buffalo vs. LA Rams betting analysis is brought to you by FanDuel Sportsbook, which has a Bet $5, Get $150 offer for new customers.

Who will win Bills vs. Rams?

Using state-of-the-art computer power and data, Dimers.com has simulated Thursday's Bills-Rams NFL game 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, currently gives the Bills a 60% chance of getting the W against the Rams in Week 1 of the NFL season.

More: Bills vs. Rams Simulated 10K Times

Bills vs. Rams Game Odds

• Spread: Rams +2 (-110), Bills -2 (-110)
• Moneyline: Rams +115, Bills -130
• Total: Over/Under 52 (-107/-107)

Point Spread, Moneyline and Over/Under

The Rams are +2 underdogs against the Bills, with -110 at Caesars Sportsbook the best odds currently available.

For the favored Bills (-2) to cover the spread, Caesars Sportsbook also has the best odds currently on offer at -110.

DraftKings Sportsbook currently has the best moneyline odds for the Rams at +115, which means you can bet $100 to profit $115, earning a total payout of $215, if they win.

On the other hand, Caesars Sportsbook currently has the best moneyline odds for the Bills at -130, where you can risk $130 to win $100, for a total payout of $230, if they come out on top.

The Over/Under sits at 52 with PointsBet, which currently has the best odds for the Over at -107, as well as the best odds for the Under at -107.

As always, make sure you check all of the online sportsbooks that are available in your state for the best NFL odds and lines.

According to DimersBOT, the Bills (-2) are a 58% chance of covering the spread, while the 52-point Over/Under is a 56% chance of going Under.

More: Predictions for Every NFL Week 1 Matchup

Best Bets for Bills vs. Rams

• Spread: Bills -2 @ -110 via Caesars Sportsbook (58% probability) 🔥
• Moneyline: Bills @ -130 via Caesars Sportsbook (60% probability)
• Total: Under 52 @ -107 via PointsBet (56% probability) 🔥

If you see a 🔥, you know you've found one of Dimers' best bets of the day across all sports.

Dimers' best bets are based on complex simulations and gambling intelligence to help you make smarter investments with the legal sportsbooks in your state.

Bills vs. Rams Prediction

Dimers.com's predicted final score for Buffalo vs. LA Rams at SoFi Stadium in Week 1 has the Bills winning 26-23.

Click or tap on See Matchup to reveal more.

Dimers has full betting coverage of this week's Bills-Rams matchup in Week 1, including pregame predictions, computer picks, and live win probabilities.

Bills vs. Rams Player Props

Who will score the first touchdown in Bills vs. Rams? The latest data is in.

Listed below are the most likely first touchdown and most likely anytime touchdown scorers for both the Bills and Rams, as well as player stat projections.

And you know what, we provide this information to you for FREE to help you choose the best prop bets for Thursday's game.

According to DimersBOT, Los Angeles' Cam Akers is most likely to score the first touchdown in Bills vs. Rams.

DimersBOT gives Akers an 11.4% chance of scoring the first TD at SoFi Stadium, while the Rams RB is a 51.5% chance of scoring an anytime touchdown.

Scroll down for the complete list of first and anytime TD scorer probabilities.

First Touchdown Scorer Probabilities

Buffalo Bills

• Stefon Diggs: 9.3% probability
• Josh Allen: 7.5% probability
• Zack Moss: 7.5% probability
• Dawson Knox: 6.7% probability
• Devin Singletary: 6.6% probability

Los Angeles Rams

• Cam Akers: 11.4% probability
• Cooper Kupp: 11.3% probability
• Allen Robinson: 7.9% probability
• Tyler Higbee: 5.0% probability
• Darrell Henderson: 3.9% probability

Anytime Touchdown Scorer Probabilities

Buffalo Bills

• Stefon Diggs: 44.1% probability
• Zack Moss: 37.3% probability
• Josh Allen: 35.8% probability
• Dawson Knox: 34.2% probability
• Gabe Davis: 32.7% probability

Los Angeles Rams

• Cam Akers: 51.5% probability
• Cooper Kupp: 50.9% probability
• Allen Robinson: 39.0% probability
• Tyler Higbee: 26.6% probability
• Darrell Henderson: 20.2% probability

Bills-Rams Projected Player Stats

Of the starting quarterbacks, the Bills' Josh Allen is projected for 259 passing yards. The Rams' Matthew Stafford is expected to throw for a whopping 270 yards.

Bills Starting QB

• Josh Allen: 259 projected yards

Rams Starting QB

• Matthew Stafford: 270 projected yards

Bills Rushing

• Devin Singletary: 51 projected yards
• Josh Allen: 38 projected yards
• Zack Moss: 29 projected yards

Rams Rushing

• Cam Akers: 67 projected yards
• Darrell Henderson: 30 projected yards
• Kyren Williams: 8 projected yards

Bills Receiving

• Stefon Diggs: 74 projected yards
• Gabe Davis: 64 projected yards
• Dawson Knox: 40 projected yards
• Isaiah McKenzie: 37 projected yards
• James Cook: 18 projected yards

Rams Receiving

• Cooper Kupp: 100 projected yards
• Allen Robinson: 58 projected yards
• Tyler Higbee: 38 projected yards
• Tutu Atwell: 24 projected yards
• Ben Skowronek: 23 projected yards

Don't forget, DimersBOT updates frequently, so keep an eye on this page for any changes to our betting insights ahead of Bills vs. Rams on Thursday September 8, 2022.

Bills vs. Rams 2022

The NFL Week 1 matchup between the Rams and Bills at SoFi Stadium is scheduled to commence at 8:20PM ET.

• Who: Buffalo Bills vs. Los Angeles Rams
• Date: Thursday September 8, 2022
• Time: 8:20PM ET / 5:20PM PT
• Venue: SoFi Stadium

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