Bills vs. Patriots Predictions and Odds - Dec 26, 2021

The New England Patriots square off with the Buffalo Bills, in what is expected to be a close NFL Week 16 game, at Gillette Stadium on Sunday, starting at 1:00PM EST.

Dimers' free betting picks for Bills vs. Patriots, plus game predictions, best odds and player props, are detailed below.

Who will win Bills vs. Patriots?

Using high-tech computer power and data, Dimers.com has simulated Sunday's Bills-Patriots NFL matchup 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, can't split the two teams, giving both the Bills and Patriots a 50% chance of winning the game.

MORE: Bills vs. Patriots Simulated 10,000 Times

Point Spread, Moneyline and Over/Under

The Patriots are currently -1.5 favorites against the Bills, with -105 at BetMGM the best odds available.

For the underdog Bills (+1.5) to cover the spread, BetMGM also has the best odds on offer at -115.

In a sign of how close this game is expected to be, both the Patriots and Bills are at minus-money betting odds on the moneyline.

PointsBet has the best moneyline odds for the Patriots at -110, which means you can risk $110 to win $100, for a total payout of $210, if they get the W.

Meanwhile, FanDuel Sportsbook has the best moneyline odds for the Bills at -104, where you can risk $104 to win $100, for a total payout of $204, if they come out on top.

The Over/Under sits at 43.5 with BetMGM, which has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, make sure you check all the sportsbooks available in your state for the best NFL odds and lines.

According to DimersBOT, the Bills (+1.5) are a 54% chance of covering the spread, while the 43.5-point Over/Under is considered an equal 50-50 chance of hitting.

MORE: Super Bowl LVI Probabilities and Odds

Best Bets for Bills vs. Patriots

• Spread: Bills +1.5 at -115 with BetMGM (54% probability)
• Moneyline: Bills Win at -104 with FanDuel Sportsbook (50% probability)
• Over/Under: Under 43.5 at -110 with BetMGM (50% probability)

Bills vs. Patriots Score Prediction

Dimers.com's predicted score for Buffalo vs. New England at Gillette Stadium on Sunday is Bills 21-21 Patriots.

Use our widget below to explore the current Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup for more.

Dimers has full betting coverage of this week's Bills-Patriots matchup, including pre-game predictions, free picks, and live win probabilities.

Bills vs. Patriots Player Props

Who will score an anytime touchdown in Bills vs. Patriots? The data is in.

Featured below are the most likely first touchdown and most likely anytime touchdown scorers for both the Bills and Patriots, as well as projected player stats.

And you know what, we provide this information to you for FREE to help you select the best prop picks for Sunday's game.

According to DimersBOT, Buffalo's Stefon Diggs is most likely to score the first TD in Bills vs. Patriots.

DimersBOT gives Diggs an 11.0% chance of scoring the first TD at Gillette Stadium, while the Bills WR is a 43.0% chance of scoring an anytime touchdown.

First Touchdown Scorer Probabilities

Buffalo Bills

• Stefon Diggs: 11.0% probability
• Josh Allen: 9.1% probability
• Devin Singletary: 8.1% probability
• Emmanuel Sanders: 6.5% probability
• Dawson Knox: 5.9% probability

New England Patriots

• Brandon Bolden: 8.2% probability
• Damien Harris: 7.9% probability
• Jakobi Meyers: 6.0% probability
• J.J. Taylor: 6.0% probability
• Jonnu Smith: 5.3% probability

Anytime Touchdown Scorer Probabilities

Buffalo Bills

• Stefon Diggs: 43.0% probability
• Josh Allen: 37.1% probability
• Devin Singletary: 33.1% probability
• Emmanuel Sanders: 28.7% probability
• Isaiah McKenzie: 25.4% probability

New England Patriots

• Brandon Bolden: 34.6% probability
• Damien Harris: 33.1% probability
• Jakobi Meyers: 26.6% probability
• J.J. Taylor: 26.3% probability
• Jonnu Smith: 23.9% probability

Projected Box Score

Of the starting quarterbacks, the Bills' Josh Allen is projected for 246 passing yards and 1.5 passing touchdowns. The Patriots' Mac Jones is expected to throw for 217 yards and 1.3 TDs.

Bills Starting QB

• Josh Allen: 246 Passing Yards, 1.5 Passing TDs

Patriots Starting QB

• Mac Jones: 217 Passing Yards, 1.3 Passing TDs

Bills Rushing

• Devin Singletary: 59 Rushing Yards, 0.2 TDs
• Josh Allen: 34 Rushing Yards, 0.4 TDs
• Isaiah McKenzie: 3 Rushing Yards, 0.0 TDs

Patriots Rushing

• Damien Harris: 45 Rushing Yards, 0.3 TDs
• Brandon Bolden: 32 Rushing Yards, 0.3 TDs
• J.J. Taylor: 31 Rushing Yards, 0.3 TDs

Bills Receiving

• Stefon Diggs: 83 Receiving Yards, 0.5 TDs
• Emmanuel Sanders: 54 Receiving Yards, 0.3 TDs
• Dawson Knox: 41 Receiving Yards, 0.2 TDs
• Isaiah McKenzie: 27 Receiving Yards, 0.2 TDs
• Devin Singletary: 12 Receiving Yards, 0.1 TDs

Patriots Receiving

• Jakobi Meyers: 44 Receiving Yards, 0.3 TDs
• Kendrick Bourne: 39 Receiving Yards, 0.2 TDs
• Hunter Henry: 33 Receiving Yards, 0.2 TDs
• Jonnu Smith: 27 Receiving Yards, 0.2 TDs
• Brandon Bolden: 25 Receiving Yards, 0.1 TDs

Don't forget, DimersBOT updates often, so keep checking this article for the latest betting insights before Bills vs. Patriots on Sunday December 26, 2021.

Bet $10, Win $200 if Bills or Patriots Score a TD

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Bills vs. Patriots 2021 Game Info

When do the Patriots play the Bills?

• Date: Sunday December 26, 2021
• Time: 1:00PM EST / 10:00AM PST
• Venue: Gillette Stadium

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