Orioles vs. Nationals Prediction: Baltimore Predicted to Win Tuesday's MLB Matchup [4/22/2025]

The Washington Nationals and Baltimore Orioles will lock horns in MLB action at Nationals Park on Tuesday, starting at 6:45PM ET.

Mitchell Parker (2-1, 1.85 ERA) will start for the Nationals, pitting him against Dean Kremer (2-2, 6.41 ERA) for the Orioles.

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Orioles as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's Baltimore-Washington game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Orioles with a win probability of 55%, compared to 45% for the Nationals."

For further insights into Tuesday's matchup, including best bets and picks, visit our interactive Orioles vs. Nationals predictions page.

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Nationals vs. Orioles Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the outcome of Tuesday's MLB matchup between the Orioles and Nationals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Orioles a 55% chance of defeating the Nationals.

According to our model, the Nationals (+1.5) have a 57% chance of covering the run line, while the 9-run over/under has a 53% chance of staying under.

Pre-Game Probabilities

Last Updated: 10:32PM, Apr 22

Moneyline

Over / Under

Run Line

Orioles

Win %

55%

45%

-130

+120

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See Matchup

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Nationals

Orioles BAL

-130

Win %

55%

45%

See Matchup

Nationals WSH

+120

Dean Kremer 2-2, 6.41 ERA

Mitchell Parker 2-1, 1.85 ERA

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Orioles vs. Nationals Odds [4/22/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Orioles vs. Nationals Picks and Best Bets

Our model's biggest edge in today's Orioles vs. Nationals matchup is on the total.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Orioles vs. Nationals Game-Day Updates and Essential Details

Tuesday's MLB matchup between the Nationals and Orioles at Nationals Park is scheduled to begin at 6:45PM ET.

• Who: Baltimore Orioles vs. Washington Nationals
• Date: Tuesday, April 22, 2025
• Time: 6:45PM ET/3:45PM PT
• Venue: Nationals Park

Dimers.com's comprehensive preview of Tuesday's Orioles vs. Nationals matchup includes our prediction, picks and the latest betting odds.

Before making any Baltimore vs. Washington picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Orioles, with a 55% win probability, will likely beat the Nationals on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Orioles vs. Nationals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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