Orioles vs. Tigers Prediction: Detroit Predicted to Win Friday's MLB Matchup [4/25/2025]

The Detroit Tigers will face the Baltimore Orioles, in what is expected to be a tight MLB game, at Comerica Park on Friday, starting at 6:40PM ET.

The Tigers will have Casey Mize (3-1, 2.22 ERA) as their starting pitcher, up against Brandon Young (0-0, 6.75 ERA) for the Orioles.

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Tigers as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Baltimore-Detroit game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Tigers' chance of winning is 51%, while the Orioles' is 49%."

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Orioles vs. Tigers predictions page.

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Tigers vs. Orioles Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Friday's MLB matchup between the Orioles and Tigers 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Tigers a 51% chance of beating the Orioles.

According to our model, the Orioles (+1.5) have a 66% chance of covering the run line, while the over/under total of 8.5 runs has an equal 50-50 chance of hitting.

Pre-Game Probabilities

Last Updated: 9:28PM, Apr 25

Moneyline

Over / Under

Run Line

Orioles

Win %

49%

51%

+105

-120

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See Matchup

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Tigers

Orioles BAL

+105

Win %

49%

51%

See Matchup

Tigers DET

-120

Brandon Young 0-0, 6.75 ERA

Casey Mize 3-1, 2.22 ERA

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Orioles vs. Tigers Odds [4/25/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Orioles vs. Tigers Picks and Best Bets

Our model's biggest edge in today's Orioles vs. Tigers matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Orioles vs. Tigers Game-Day Updates and Essential Details

Friday's MLB matchup between the Tigers and Orioles at Comerica Park is scheduled to start at 6:40PM ET.

• Who: Baltimore Orioles vs. Detroit Tigers
• Date: Friday, April 25, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Comerica Park

Dimers.com's comprehensive preview of Friday's Orioles vs. Tigers matchup includes our prediction, picks and the latest betting odds.

Before making any Baltimore vs. Detroit picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Tigers, with a 51% win probability, will likely beat the Orioles on Friday.

AI and automation have enhanced this article to quickly deliver accurate Orioles vs. Tigers insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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