Astros vs. Orioles Prediction and Odds - Sep 25, 2022

The Baltimore Orioles and Houston Astros lock horns in MLB at Oriole Park at Camden Yards on Sunday, starting at 1:05PM ET.

Austin Voth (5-3, 4.32 ERA) will start on the mound for the Orioles, while the Astros are going with Cristian Javier (10-9, 2.77 ERA).

Dimers' best betting picks for Astros vs. Orioles, as well as game predictions and best odds, are detailed in this article.

Who will win Astros vs. Orioles?

Using trusted machine learning and data, Dimers.com has simulated Sunday's Astros-Orioles MLB matchup 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, currently gives the Astros a 59% chance of beating the Orioles.

More: Free Betting Analysis for Astros vs. Orioles

Astros vs. Orioles Current Odds

• Run Line: Orioles +1.5 (-125), Astros -1.5 (+105)
• Moneyline: Orioles +135, Astros -155
• Total: Over/Under 8 (-120/-102)

Run Line, Moneyline and Over/Under

The Orioles are +1.5 underdogs versus the Astros, with -125 at BetMGM the best odds currently available.

For the favored Astros (-1.5) to cover the run line, BetMGM also has the best odds currently on offer at +105.

BetMGM currently has the best moneyline odds for the Orioles at +135, which means you can bet $100 to profit $135, earning a total payout of $235, if they win.

Meanwhile, DraftKings Sportsbook currently has the best moneyline odds for the Astros at -155, where you can risk $155 to win $100, for a total payout of $255, if they come out on top.

The Over/Under for total runs scored is set at 8 with FanDuel Sportsbook, which currently has the best odds for the Over at -120, as well as the best odds for the Under at -102.

As always, make sure you check all of the sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Orioles (+1.5) are a 53% chance of covering the run line, while the Over/Under total of 8 runs is a 60% chance of going Over.

More: Best Bets for Every MLB Game

Best Bets for Astros vs. Orioles

• Run Line: Orioles +1.5 @ -125 via BetMGM (53% probability)
• Moneyline: Orioles @ +135 via BetMGM
• Total: Over 8 @ -120 via FanDuel Sportsbook (60% probability) 🔥

When you see a 🔥, you know it's one of our best free picks of the day across all sports.

Our best bets are based on complex modeling and gambling expertise to bring you the best possible plays 24/7/365.

While the Astros are more likely to win the game, according to DimersBOT, betting on the Orioles moneyline is the best option because of the edge found when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges seen here at Dimers is pivotal to being profitable in the long run.

Astros vs. Orioles Prediction

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Dimers has full coverage of Sunday's Astros-Orioles matchup, including pregame predictions, free betting picks, and live scores.

Don't forget, DimersBOT updates frequently, so check this page for the latest betting analysis before Astros vs. Orioles on Sunday September 25, 2022.

Astros vs. Orioles 2022 Game Info

Sunday's matchup between the Orioles and Astros at Oriole Park at Camden Yards is scheduled to start at 1:05PM ET.

• Who: Houston Astros vs. Baltimore Orioles
• Date: Sunday September 25, 2022
• Time: 1:05PM ET / 10:05AM PT
• Venue: Oriole Park at Camden Yards

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Want more MLB analysis like this?

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That's right, our predictive analytics model then compares those odds (aka Vegas odds) against its own probabilities to find edges in the markets. This allows us to write the most reliable MLB betting previews and get the jump on the public and the sportsbooks.

It's only a click away, so why not see for yourself?

Finally, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities paired with the best odds to win the World Series.