Astros vs. Guardians Prediction and Odds - Aug 6, 2022

The Cleveland Guardians and Houston Astros meet in MLB at Progressive Field on Saturday, starting at 6:10PM ET.

The Guardians will have Cal Quantrill (7-5, 4.08 ERA) start, while the Astros will counter with Luis Garcia (8-7, 3.81 ERA).

Dimers' top betting picks for Astros vs. Guardians, as well as game predictions and best odds, are detailed below.

Who will win Astros vs. Guardians?

Using trusted computer power and data, Dimers.com has simulated Saturday's Astros-Guardians MLB matchup 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, currently gives the Astros a 58% chance of defeating the Guardians.

More: Free Betting Guide for Astros vs. Guardians

Astros vs. Guardians Game Odds

• Run Line: Guardians +1.5 (-114), Astros -1.5 (+100)
• Moneyline: Guardians +143, Astros -160
• Total: Over/Under 8.5 (-105/+100)

Run Line, Moneyline and Over/Under

The Guardians are currently +1.5 underdogs versus the Astros, with -114 at FanDuel Sportsbook the best odds currently available.

For the favored Astros (-1.5) to cover the run line, BetMGM has the best odds currently on the market at +100.

Caesars Sportsbook currently has the best moneyline odds for the Guardians at +143. That means you can bet $100 to profit $143, earning a total payout of $243, if they win.

On the other hand, BetMGM currently has the best moneyline odds for the Astros at -160, where you can risk $160 to win $100, for a total payout of $260, if they come out on top.

The Over/Under sits at 8.5 with DraftKings Sportsbook, which currently has the best odds for the Over at -105, while Caesars Sportsbook currently has the best odds for the Under at +100.

As always, check out the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 55% chance of covering the run line, while the Over/Under total of 8.5 runs is a 53% chance of going Over.

More: Today's Best Bets for All Major Sports

Best Bets for Astros vs. Guardians

• Run Line: Guardians +1.5 @ -114 via FanDuel Sportsbook (55% probability)
• Moneyline: Guardians @ +143 via Caesars Sportsbook (1.0% edge)
• Total: Over 8.5 @ -105 via DraftKings Sportsbook (53% probability)

Our best bets are based on world-class simulations and betting intelligence to serve you the best possible plays 24/7.

While the Astros are more likely to win the game, according to DimersBOT, taking the Guardians moneyline is the best option due to the 1.0% edge found when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges published on Dimers is one of the keys to achieving long-term profitability.

Astros vs. Guardians Prediction

Use our dynamic widget below to explore up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Houston vs. Cleveland, and click or tap on See Matchup to reveal more.

Dimers has full betting coverage of Saturday's Astros-Guardians matchup, including pregame predictions, free picks, and live win probabilities.

Remember, DimersBOT updates regularly, so refresh this page for the latest betting insights before Astros vs. Guardians on Saturday August 6, 2022.

Best Betting Promo for Astros vs. Guardians

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Note: When you click or tap on a link on Dimers that leads to a third-party website that we have a commercial relationship with (such as a sportsbook), we may earn a referral fee.

Astros vs. Guardians 2022 Game Info

Saturday's action between the Guardians and Astros at Progressive Field is scheduled to start at 6:10PM ET.

• Who: Cleveland Guardians vs. Houston Astros
• Date: Saturday August 6, 2022
• Time: 6:10PM ET / 3:10PM PT
• Venue: Progressive Field

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Want more MLB analysis like this?

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We use the power of predictive analytics to find value in the markets so we can produce the most comprehensive MLB betting previews available. We do this by comparing our in-house probabilities against the sportsbooks' odds (aka Vegas odds) as soon as they go live.

So, get ahead of the game and beat the bookies today – it's only a click away.

Lastly, Dimers' MLB Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities compared to the best odds on the market.