Arizona vs. Duke Prediction: Who Will Advance to the Elite Eight?

Arizona will take on Duke in Sweet 16 March Madness action at the Prudential Center on Thursday night, with tipoff set for 9:39PM ET.

Early this morning, following the release of new player stat projections and odds for both Duke and Arizona, our March Madness simulator updated its Duke-Arizona Sweet Sixteen prediction and best bets. The results are below.

Game-Day Details: Arizona vs. Duke

• Who: Arizona vs. Duke

• Date: Thursday, March 27, 2025

• Time: 9:39PM ET / 6:39PM PT

• Venue: Prudential Center

• March Madness Stage: Sweet 16

Arizona vs. Duke Prediction, Picks and Odds

Dimers’ machine-learning model projects a final score of Duke 82, Arizona 72 after simulating the Sweet 16 matchup 10,000 times.

Based on these simulations:

• Duke has an 81% chance of advancing.

• Arizona’s win probability is 19%.

The current point spread has Duke favored by 9.5 points, with the total set at 153.5. The best odds for Duke -9.5 are listed at -108, while the best available price for the under is -105.

Our projections give the Under 153.5 a slight edge at 50.2% probability, though the overall edge is minimal at -1.0%.

Arizona vs. Duke Odds for March 27, 2025

We’ve researched the top available odds for Thursday’s Sweet 16 showdown:

All odds are accurate at the time of publication and subject to change.

Arizona vs. Duke Picks and Best Bets

According to the Dimers Pro best bets page:

• The best bet with the highest win probability (50.7%) is Duke -9.5, despite a slight negative edge of -1.2%.

• The Under 153.5 comes in close behind with a 50.2% chance of hitting.

• If you’re chasing a longshot, Arizona to win outright at +430 carries value—but just an 18.7% probability.

All best bets are tracked and updated regularly inside Dimers Pro. Local Duke and Arizona fans using this data to bet on the Sweet 16 can unlock $150 in bonus bets from Bet365 with the exclusive bonus code "DIMERS", which is now trending in both North Carolina and Arizona.

For more picks, predictions, and expert analysis on the 2025 NCAA Tournament, head to Dimers.com.