Diamondbacks vs. Marlins Prediction: Arizona Predicted to Win Wednesday's MLB Matchup [4/16/2025]

The Miami Marlins will take on the Arizona Diamondbacks in MLB action at loanDepot park on Wednesday, beginning at 6:40PM ET.

The Marlins will start Max Meyer (1-1, 2.00 ERA), while the Diamondbacks have opted for Brandon Pfaadt (2-1, 3.50 ERA).

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects the Diamondbacks as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Arizona-Miami game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Diamondbacks' chance of winning at 57%, with the Marlins at 43%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Diamondbacks vs. Marlins predictions page.

Diamondbacks vs. Diamondbacks Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Wednesday's MLB game between the Diamondbacks and Marlins 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Diamondbacks a 57% chance of defeating the Marlins.

According to our model, the Marlins (+1.5) have a 57% chance of covering the run line, while the 8.5-run over/under has a 53% chance of staying under.

Diamondbacks vs. Marlins Odds [4/16/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Diamondbacks	Marlins
Run Line	-1.5 (+125)	+1.5 (-135)
Moneyline	-145	+124
Total	o8.5 (-112)	u8.5 (-102)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Diamondbacks vs. Marlins Picks and Best Bets

Our model's biggest edge in today's Diamondbacks vs. Marlins matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Diamondbacks vs. Marlins Game-Day Updates and Essential Details

Wednesday's MLB action between the Marlins and Diamondbacks at loanDepot park is scheduled to begin at 6:40PM ET.

• Who: Arizona Diamondbacks vs. Miami Marlins
• Date: Wednesday, April 16, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: loanDepot park

Dimers.com's in-depth preview of Wednesday's Diamondbacks vs. Marlins matchup includes our prediction, picks and the latest betting odds.

Before making any Arizona vs. Miami picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Diamondbacks, with a 57% win probability, will likely beat the Marlins on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Diamondbacks vs. Marlins insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay informed with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest predictions for the World Series, American League, National League and each division.