Diamondbacks vs. Cubs Prediction: Cubs Predicted to Win Sunday's MLB Matchup [4/20/2025]

The Chicago Cubs will face the Arizona Diamondbacks in MLB action at Wrigley Field on Sunday, commencing at 2:20PM ET.

Jameson Taillon (1-1, 5.40 ERA) will be on the bump for the Cubs, up against Merrill Kelly (3-1, 5.57 ERA) for the Diamondbacks.

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Arizona-CHI Cubs game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Cubs with a win probability of 53%, while the Diamondbacks have 47%."

For expanded analysis of Sunday's matchup, including best bets and picks, visit our interactive Diamondbacks vs. Cubs predictions page.

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Diamondbacks vs. Diamondbacks Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the outcome of Sunday's MLB matchup between the Diamondbacks and Cubs 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Cubs a 53% chance of beating the Diamondbacks.

According to our model, the Diamondbacks (+1.5) have a 66% chance of covering the run line, while the 7.5-run over/under has a 53% chance of going over.

Pre-Game Probabilities

Last Updated: 6:28PM, Apr 20

Moneyline

Over / Under

Run Line

D-Backs

Win %

47%

53%

+120

-139

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Cubs

D-Backs ARI

+120

Win %

47%

53%

See Matchup

Cubs CHC

-139

Merrill Kelly 3-1, 5.57 ERA

Jameson Taillon 1-1, 5.40 ERA

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Diamondbacks vs. Cubs Odds [4/20/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Diamondbacks vs. Cubs Picks and Best Bets

Our model's biggest edge in today's Diamondbacks vs. Cubs matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Diamondbacks vs. Cubs Game-Day Updates and Essential Details

Sunday's MLB game between the Cubs and Diamondbacks at Wrigley Field is scheduled to start at 2:20PM ET.

• Who: Arizona Diamondbacks vs. Chicago Cubs
• Date: Sunday, April 20, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's in-depth preview of Sunday's Diamondbacks vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Arizona vs. CHI Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Cubs, with a 53% win probability, will likely beat the Diamondbacks on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Diamondbacks vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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