Diamondbacks vs. Cubs Prediction: Cubs Predicted to Win Saturday's MLB Matchup [4/19/2025]

The Chicago Cubs and Arizona dbacks will lock horns in MLB action at Wrigley Field on Saturday, starting at 2:20PM ET.

The Cubs will start Ben Brown (2-1, 5.09 ERA), up against Zac Gallen (1-2, 4.64 ERA) for the Diamondbacks.

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects the Cubs as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's Arizona-CHI Cubs game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Cubs are more likely to win, while the Diamondbacks have a lower chance of victory."

For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Diamondbacks vs. Cubs predictions page.

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Diamondbacks vs. Diamondbacks Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Saturday's MLB matchup between the Diamondbacks and Cubs 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Cubs a 51% chance of defeating the Diamondbacks.

According to our model, the Cubs (+1.5) have a 65% chance of covering the run line, while the over/under total of 7.5 runs has an equal 50-50 chance of hitting.

Pre-Game Probabilities

Last Updated: 6:28PM, Apr 19

Moneyline

Over / Under

Run Line

D-Backs

Win %

50%

50%

+110

-117

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See Matchup

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Cubs

D-Backs ARI

+110

Win %

50%

50%

See Matchup

Cubs CHC

-117

Zac Gallen 1-2, 4.64 ERA

Ben Brown 2-1, 5.09 ERA

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Diamondbacks vs. Cubs Odds [4/19/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Diamondbacks vs. Cubs Picks and Best Bets

Our model's biggest edge in today's Diamondbacks vs. Cubs matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Diamondbacks vs. Cubs Game-Day Updates and Essential Details

Saturday's MLB matchup between the Cubs and Diamondbacks at Wrigley Field is scheduled to start at 2:20PM ET.

• Who: Arizona Diamondbacks vs. Chicago Cubs
• Date: Saturday, April 19, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's in-depth preview of Saturday's Diamondbacks vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Arizona vs. CHI Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cubs, with a 51% win probability, will likely beat the Diamondbacks on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Diamondbacks vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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