Diamondbacks vs. Cubs Prediction: Arizona Predicted to Win Friday's MLB Matchup [4/18/2025]

The Chicago Cubs will square off with the Arizona Diamondbacks in MLB action at Wrigley Field on Friday, commencing at 2:20PM ET.

The Cubs will have Colin Rea (0-0, 1.00 ERA) as their starting pitcher, up against Corbin Burnes (0-1, 5.28 ERA) for the Diamondbacks.

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Diamondbacks as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Arizona-CHI Cubs game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Diamondbacks' chance of winning is 52%, while the Cubs' is 48%."

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Diamondbacks vs. Cubs predictions page.

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Diamondbacks vs. Diamondbacks Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Friday's MLB game between the Diamondbacks and Cubs 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Diamondbacks a 52% chance of defeating the Cubs.

According to our model, the Cubs (+1.5) have a 59% chance of covering the run line, while the over/under total of 11 runs has a 57% chance of staying under.

Pre-Game Probabilities

Last Updated: 6:28PM, Apr 18

Moneyline

Over / Under

Run Line

D-Backs

Win %

52%

48%

-108

-104

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See Matchup

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Cubs

D-Backs ARI

-108

Win %

52%

48%

See Matchup

Cubs CHC

-104

Corbin Burnes 0-1, 5.28 ERA

Colin Rea 0-0, 1.00 ERA

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Diamondbacks vs. Cubs Odds [4/18/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Diamondbacks vs. Cubs Picks and Best Bets

Our model's strongest edge in today's Diamondbacks vs. Cubs matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Diamondbacks vs. Cubs Game-Day Updates and Essential Details

Friday's MLB action between the Cubs and Diamondbacks at Wrigley Field is scheduled to start at 2:20PM ET.

• Who: Arizona Diamondbacks vs. Chicago Cubs
• Date: Friday, April 18, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's full preview of Friday's Diamondbacks vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Arizona vs. CHI Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Diamondbacks, with a 52% win probability, will likely beat the Cubs on Friday.

AI and automation have enhanced this article to quickly deliver accurate Diamondbacks vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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