Cardinals vs. Panthers Prediction: Arizona Predicted to Win in NFL Week 16 [2024]

The Carolina Panthers will square off with the favored Arizona Cardinals in NFL Week 16 action at Bank of America Stadium on Sunday, beginning at 1:00PM ET.

Based on updated simulation results, Dimers' proven NFL model (see Dimers Pro for full access) predicts the Cardinals as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Arizona-Carolina game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Cardinals with a win probability of 68%, while the Panthers have 32%."

This updated Cardinals vs. Panthers betting preview builds on my early Cardinals vs. Panthers prediction that I released at the start of the week.

For expanded analysis of today’s game, including the predicted score, best bets and player prop picks, visit our interactive Cardinals vs. Panthers predictions page.

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Cardinals vs. Panthers Game-Day Updates and Essential Details

The NFL Week 16 action between the Panthers and Cardinals at Bank of America Stadium is scheduled to start at 1:00PM ET.

• Who: Arizona Cardinals vs. Carolina Panthers
• Date: Sunday, December 22, 2024
• Time: 1:00PM ET/10:00AM PT
• Venue: Bank of America Stadium
• Tickets: Get tickets for the game on Ticketmaster
• Merchandise: Buy Panthers and Cardinals gear at Fanatics

Dimers.com's full preview of Sunday's Cardinals vs. Panthers matchup includes our prediction, picks and the latest betting odds.

Before making any Arizona vs. Carolina picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

Cardinals vs. Panthers Predictions

Using trusted machine learning and data, we have simulated the outcome of Sunday's NFL game between the Cardinals and Panthers 10,000 times as part of our NFL predictions coverage.

Our independent predictive model currently gives the Cardinals a 68% chance of beating the Panthers in Week 16 of the NFL season. Our predicted final score has the Cardinals winning 25-20.

According to our model, the bookmakers have got it right, and the Cardinals and Panthers each have a 50% chance of covering the spread, while the 46.5-point over/under has a 51% chance of going over.

Along with our Cardinals vs. Panthers predictions, we've also prepared the following for today’s action:

• NFL Best Bets for Week 16
• NFL Player Props for Week 16
• Touchdown Predictions for Week 16

Cardinals vs. Panthers Odds

We have researched the best betting odds in America for this game, which are listed here:

Bet Type	Cardinals	Panthers
Spread	-5.5 (-110)	+5.5 (-105)
Moneyline	-245	+215
Total	o46.5 (-110)	u46.5 (-110)

All odds are correct at the time of publication and are subject to change.

Cardinals vs. Panthers Picks

Our model's biggest edge in today's Cardinals vs. Panthers matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best NFL picks for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Cardinals vs. Panthers TD Scorers

Who will score the first touchdown in Cardinals vs. Panthers?

According to our model, Arizona's James Conner is most likely to score the first TD in Cardinals vs. Panthers.

Our projections give Conner a 14.6% chance of scoring the first TD at Bank of America Stadium, while the Cardinals RB is a 57.2% chance of reaching the end zone at any point in the game.

First Touchdown Scorer Predictions

Arizona Cardinals

Player	First TD Probability
James Conner	14.6%
Marvin Harrison	9.8%
Trey McBride	9.2%

Carolina Panthers

Player	First TD Probability
Chuba Hubbard	11.6%
Adam Thielen	6.4%
David Moore	5.8%

Anytime Touchdown Scorer Predictions

Arizona Cardinals

Player	Anytime TD Probability
James Conner	57.2%
Marvin Harrison	43.1%
Kyler Murray	40.4%

Carolina Panthers

Player	Anytime TD Probability
Chuba Hubbard	49.3%
Adam Thielen	30.1%
Jalen Coker	27.2%

For a complete analysis of the most likely first and anytime TD scorers this week, see our NFL Week 16 touchdown scorer predictions

Cardinals vs Panthers Player Props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Cardinals and Panthers. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Cardinals-Panthers page now to access every player prop projection.

Cardinals vs. Panthers Quarterbacks

Of the starting quarterbacks, the Cardinals' Kyler Murray is projected to throw for more yards than the Panthers' Bryce Young.

Cardinals Rushing

James Conner, Kyler Murray and DeeJay Dallas are projected to be the leading rushers for the Cardinals.

Player	Position
James Conner	RB
Kyler Murray	QB
DeeJay Dallas	RB

Panthers Rushing

Chuba Hubbard, Bryce Young and Mike Boone are expected to lead the Panthers in rushing yards.

Player	Position
Chuba Hubbard	RB
Bryce Young	QB
Mike Boone	RB

Cardinals Receiving

Trey McBride, Marvin Harrison, Michael Wilson, James Conner and Elijah Higgins are projected to top the receiving yards for the Cardinals.

Player	Position
Trey McBride	TE
Marvin Harrison	WR
Michael Wilson	WR
James Conner	RB
Elijah Higgins	TE

Panthers Receiving

Adam Thielen, Jalen Coker, David Moore, Ja'Tavion Sanders and Chuba Hubbard are projected to lead the Panthers in receiving yards.

Player	Position
Adam Thielen	WR
Jalen Coker	WR
David Moore	WR
Ja'Tavion Sanders	TE
Chuba Hubbard	RB

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Conclusion

We predict the Cardinals, with a 68% win probability, will likely beat the Panthers in Week 16 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Panthers insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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