49ers vs. Seahawks Week 15 Prediction and Odds - Dec 15, 2022

The Seattle Seahawks take on the San Francisco 49ers in NFL Week 15 action at Lumen Field on Thursday, starting at 8:15PM ET.

Dimers' top betting picks for 49ers vs. Seahawks, as well as game predictions, betting odds and touchdown scorer probabilities, are featured in this article.

Who will win 49ers vs. Seahawks?

Based on advanced machine learning and data, Dimers.com has simulated Thursday's 49ers-Seahawks NFL game 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, currently gives the 49ers a 62% chance of beating the Seahawks in Week 15 of the NFL season.

More: 49ers vs. Seahawks Simulated 10K Times

49ers vs. Seahawks Week 15 Odds

• Spread: Seahawks +3.5 (-120), 49ers -3.5 (+105)
• Moneyline: Seahawks +158, 49ers -175
• Total: Over/Under 42.5 (-110/-110)

Point Spread, Moneyline and Over/Under

The Seahawks are +3.5 underdogs versus the 49ers, with -120 at PointsBet the best odds currently available.

For the favored 49ers (-3.5) to cover the spread, PointsBet also has the best odds currently on the market at +105.

Caesars Sportsbook currently has the best moneyline odds for the Seahawks at +158, which means you can bet $100 to profit $158, earning a total payout of $258, if they win.

On the other hand, BetMGM currently has the best moneyline odds for the 49ers at -175, where you can risk $175 to win $100, for a total payout of $275, if they come out on top.

The Over/Under is set at 42.5 with Caesars Sportsbook, which currently has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, make sure you check the sportsbooks you have access to in your state for the best NFL odds and lines.

According to DimersBOT, the Seahawks (+3.5) are a 56% chance of covering the spread, while the 42.5-point Over/Under is a 56% chance of going Over.

More: Predictions for Every NFL Game

Best Bets for 49ers vs. Seahawks

• Spread: Seahawks +3.5 @ -120 via PointsBet (56% probability)
• Moneyline: Seahawks @ +158 via Caesars Sportsbook
• Total: Over 42.5 @ -110 via Caesars Sportsbook (56% probability)

Our best bets are based on detailed simulations and gambling expertise to bring you the best possible plays every time.

While the 49ers are more likely to win the game, according to DimersBOT, taking the Seahawks moneyline is the best option because of the edge identified when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges published on Dimers.com is pivotal to achieving long-term profitability.

49ers vs. Seahawks Prediction

Dimers.com's predicted final score for San Francisco vs. Seattle at Lumen Field in Week 15 has the 49ers winning 23-20.

Click or tap on See Matchup for more.

Dimers has full betting coverage of this week's 49ers-Seahawks matchup in Week 15, including pregame predictions, free picks, and live win probabilities.

49ers vs. Seahawks Player Props

Who will score the first touchdown in 49ers vs. Seahawks? The latest data is in.

Featured below are the most likely first touchdown and most likely anytime touchdown scorers for both the 49ers and Seahawks, as well as player stat projections.

And you know what, we provide this information to you for FREE to help you choose the best prop picks for Thursday's game.

According to DimersBOT, San Francisco's Christian McCaffrey is most likely to score the first TD in 49ers vs. Seahawks.

DimersBOT gives McCaffrey a 19.0% chance of getting in for six first at Lumen Field, while the 49ers RB is a 64.0% chance of registering an anytime touchdown.

Scroll down for our full list of first and anytime TD scorer probabilities.

First Touchdown Scorer Probabilities

San Francisco 49ers

• Christian McCaffrey: 19.0% probability
• Brandon Aiyuk: 8.5% probability
• George Kittle: 6.4% probability
• Jordan Mason: 5.6% probability
• Jauan Jennings: 4.4% probability

Seattle Seahawks

• Kenneth Walker: 10.0% probability
• DK Metcalf: 7.4% probability
• Tyler Lockett: 6.7% probability
• Will Dissly: 3.6% probability
• Travis Homer: 3.4% probability

Anytime Touchdown Scorer Probabilities

San Francisco 49ers

• Christian McCaffrey: 64.0% probability
• Brandon Aiyuk: 34.6% probability
• George Kittle: 27.9% probability
• Jordan Mason: 24.0% probability
• Jauan Jennings: 19.5% probability

Seattle Seahawks

• Kenneth Walker: 41.3% probability
• DK Metcalf: 32.0% probability
• Tyler Lockett: 28.9% probability
• Will Dissly: 16.4% probability
• Travis Homer: 15.3% probability

49ers-Seahawks Projected Player Stats

Of the starting quarterbacks, the 49ers' Brock Purdy is projected for 212 passing yards, while the Seahawks' Geno Smith is expected to throw for 222 yards.

49ers Starting QB

• Brock Purdy: 212 projected yards

Seahawks Starting QB

• Geno Smith: 222 projected yards

49ers Rushing

• Christian McCaffrey: 71 projected yards
• Jordan Mason: 31 projected yards
• Brock Purdy: 15 projected yards

Seahawks Rushing

• Kenneth Walker: 61 projected yards
• Travis Homer: 19 projected yards
• Geno Smith: 17 projected yards

49ers Receiving

• Brandon Aiyuk: 66 projected yards
• George Kittle: 45 projected yards
• Christian McCaffrey: 45 projected yards
• Jauan Jennings: 35 projected yards
• Ray-Ray McCloud: 21 projected yards

Seahawks Receiving

• Tyler Lockett: 80 projected yards
• DK Metcalf: 57 projected yards
• Noah Fant: 33 projected yards
• Marquise Goodwin: 30 projected yards
• Will Dissly: 26 projected yards

Don't forget, DimersBOT updates frequently, so keep an eye on this article for any changes to our betting insights ahead of 49ers vs. Seahawks on Thursday December 15, 2022.

49ers vs. Seahawks 2022

The NFL Week 15 game between the Seahawks and 49ers at Lumen Field is scheduled to start at 8:15PM ET.

• Who: San Francisco 49ers vs. Seattle Seahawks
• Date: Thursday December 15, 2022
• Time: 8:15PM ET / 5:15PM PT
• Venue: Lumen Field

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