49ers vs. Rams Week 2 Prediction and Odds - September 17, 2023

The Los Angeles Rams will square off with the favored San Francisco 49ers in NFL Week 2 action at SoFi Stadium on Sunday, commencing at 4:05PM ET.

Dimers' best betting picks for 49ers vs. Rams, plus game predictions, betting odds and projected player stats, are featured below.

Today's San Francisco vs. LA Rams betting analysis is sponsored by Bet365, which has an awesome Bet $1, Get $365 in Bonus Bets offer for new users.

Who Will Win: 49ers vs. Rams

Using state-of-the-art computer power and data, Dimers.com has simulated Sunday's 49ers-Rams NFL game 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, gives the 49ers a 73% chance of getting the W against the Rams in Week 2 of the NFL season.

More: 49ers vs. Rams Simulated 10,000 Times

49ers vs. Rams Odds

• Spread: Rams +9.5 (-115), 49ers -9.5 (-115)
• Moneyline: Rams +325, 49ers -350
• Total: Over/Under 44.5 (-110/-118)

The Rams are +9.5 underdogs versus the 49ers, with -115 at DraftKings Sportsbook the best odds currently available.

For the favored 49ers (-9.5) to cover the spread, DraftKings Sportsbook also has the best odds currently on offer at -115.

DraftKings Sportsbook currently has the best moneyline odds for the Rams at +325. That means you can bet $100 to profit $325, earning a total payout of $425, if they win.

Elsewhere, BetMGM currently has the best moneyline odds for the 49ers at -350, where you can risk $350 to win $100, for a total payout of $450, if they come out on top.

The Over/Under for total points scored is set at 44.5 with DraftKings Sportsbook, which currently has the best odds for the Over at -110, while FanDuel Sportsbook currently has the best odds for the Under at -118.

As always, check out the sportsbooks you have access to in your state for the best NFL odds and lines.

According to DimersBOT, the Rams (+9.5) have a 61% chance of covering the spread, while the Over/Under total of 44.5 points has a 52% chance of going Over.

More: Predictions for Every NFL Game

Best Bets: 49ers vs. Rams

• Spread: Rams +9.5 @ -115 via DraftKings Sportsbook (61% probability) 🔥
• Moneyline: Rams @ +325 via DraftKings Sportsbook (3.2% edge)
• Total: Over 44.5 @ -110 via DraftKings Sportsbook (52% probability)

If you see a 🔥, that means it's one of Dimers' best bets today across all sports.

Our best bets are based on detailed modeling and gambling intelligence to help you make more informed investments with the legal sportsbooks in America.

While the 49ers are more likely to win the game, according to DimersBOT, betting on the Rams moneyline is the best option due to the 3.2% edge found when comparing our data-led probabilities to the sportsbooks' odds currently available.

Taking advantage of the edges seen on Dimers is crucial to being profitable in the long run.

49ers vs. Rams Prediction

Dimers.com's predicted final score for San Francisco vs. LA Rams at SoFi Stadium in Week 2 has the 49ers prevailing 25-19.

Click or tap on See Matchup for more information.

Dimers has full betting coverage of this week's 49ers-Rams game in Week 2, including pregame predictions, free picks, and live win probabilities.

49ers vs. Rams Player Props

Who will score the first touchdown in 49ers vs. Rams? The latest data is in.

Featured below are the most likely first touchdown and most likely anytime touchdown scorers for both the 49ers and Rams, as well as player stat projections.

And you know what, we provide this information to you for FREE to help you select the best prop picks for Sunday's game.

According to DimersBOT, San Francisco's Christian McCaffrey is most likely to score the first touchdown in 49ers vs. Rams.

DimersBOT gives McCaffrey a 17.0% chance of getting in for six first at SoFi Stadium, while the 49ers RB is a 60.5% chance of scoring an anytime touchdown.

Scroll down for our complete list of first and anytime TD scorer probabilities, which provide a great avenue for you to use this DraftKings Sportsbook offer, which unlocks $200 in bonus bets from a $5 bet on any of the below players.

First Touchdown Scorer Probabilities

San Francisco 49ers

• Christian McCaffrey: 17.0% probability
• Brandon Aiyuk: 9.9% probability
• Deebo Samuel: 8.7% probability
• George Kittle: 8.2% probability
• Elijah Mitchell: 4.8% probability

Los Angeles Rams

• Kyren Williams: 8.2% probability
• Cam Akers: 7.0% probability
• Tyler Higbee: 5.0% probability
• Puka Nacua: 4.8% probability
• Van Jefferson: 4.1% probability

Anytime Touchdown Scorer Probabilities

San Francisco 49ers

• Christian McCaffrey: 60.5% probability
• Brandon Aiyuk: 39.8% probability
• Deebo Samuel: 36.8% probability
• George Kittle: 34.2% probability
• Elijah Mitchell: 22.6% probability

Los Angeles Rams

• Kyren Williams: 36.1% probability
• Cam Akers: 32.4% probability
• Tyler Higbee: 23.8% probability
• Puka Nacua: 22.6% probability
• Van Jefferson: 20.2% probability

49ers-Rams Projected Player Stats

Of the starting quarterbacks, the 49ers' Brock Purdy is projected for 248 passing yards, while the Rams' Matthew Stafford is expected to throw for 253 yards.

49ers Starting QB

• Brock Purdy: 248 projected yards

Rams Starting QB

• Matthew Stafford: 253 projected yards

49ers Rushing

• Christian McCaffrey: 77 projected yards
• Elijah Mitchell: 28 projected yards
• Deebo Samuel: 12 projected yards

Rams Rushing

• Cam Akers: 44 projected yards
• Kyren Williams: 38 projected yards
• Zach Evans: 11 projected yards

49ers Receiving

• Brandon Aiyuk: 63 projected yards
• Deebo Samuel: 56 projected yards
• George Kittle: 54 projected yards
• Christian McCaffrey: 36 projected yards
• Jauan Jennings: 21 projected yards

Rams Receiving

• Puka Nacua: 53 projected yards
• Van Jefferson: 39 projected yards
• Tutu Atwell: 36 projected yards
• Tyler Higbee: 35 projected yards
• Kyren Williams: 19 projected yards

Remember, DimersBOT updates regularly, so keep checking this article for the latest betting insights before 49ers vs. Rams on Sunday September 17, 2023.

49ers vs. Rams 2023

The NFL Week 2 matchup between the Rams and 49ers at SoFi Stadium is scheduled to begin at 4:05PM ET.

• Who: San Francisco 49ers vs. Los Angeles Rams
• Date: Sunday September 17, 2023
• Time: 4:05PM ET / 1:05PM PT
• Venue: SoFi Stadium

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Make Informed Sports Betting Decisions Today

Dimers' predictions are based on 10,000 simulations per game, using reliable and up-to-date data sources and analytical methods.

While these 49ers vs. Rams picks can help you make informed decisions, it's vital that you only bet what you can afford to lose and manage your bankroll effectively.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

What NFL Games Are on Today?

The 49ers and Rams aren't the only two NFL teams you can bet on today. DimersBOT never stops and we've got picks and top bets for every single NFL matchup via our NFL predictions. Not only do we provide with you great predictions, but we also have recommended bets for the Spread, Over/Under and Moneyline. Sound good? Check it out now!

In addition to our leading NFL predictions, Dimers also offers the best NFL prop bets today, projecting passing yards, touchdowns, and more against the best odds available every single day of the NFL season.